BACKGROUND Pertussis occurs in older children, adolescents and adults due to waning immunity after primary vaccination. Booster vaccination for pre-school children has been recommended in Italy since 1999. In this study (NCT00871000), the immunogenicity, safety and reactogenicity of a booster dose of reduced-antigen content diphtheria-tetanus-acellular pertussis-inactivated poliovirus vaccine (...

BACKGROUND & AIMS Since 2009/10, a 10- and a 13-valent pneumococcal conjugate vaccine (PCV) are available, but only the 10-valent vaccine is now being used for the children in the Netherlands. As the vaccines differ in number of serotypes, antigen concentration, and carrier proteins this study was designed to directly compare quantity and quality of the antibody responses induced by PCV10 and P...

Thirty-one bison heifers were randomly assigned to receive saline or a single vaccination with 10(10) CFU of Brucella abortus strain RB51. Some vaccinated bison were randomly selected for booster vaccination with RB51 at 11 months after the initial vaccination. Mean antibody responses to RB51 were greater (P < 0.05) in vaccinated bison after initial and booster vaccination than in nonvaccinated...

We will describe measurements of the beam in the Fermilab Booster during the first five milliseconds. Most of the particle losses in the Booster are over after the first few milliseconds. At high intensity of 4 × 10 the transmission is 75%. Such high beam loss can be a limiting factor for future high repetition rate operation of the Booster. The evidence, although indirect, suggests that the lo...

The NSLS-II Injector System Diagnostics will provide instrumentation in the linac, Booster, Transfer Lines and Beam Dumps for measuring key beam parameters. These instruments will be adequate for staged commissioning of NSLS-II injectors, and will allow sufficient beam diagnostics for tune-up and top-up operations. This paper summarizes the status of the NSLS-II injector system diagnostics, foc...

Individual particle orbits in a beam will respond to both external focusing and accelerating forces as well as internal space-charge forces. The external forces will reflect unavoidable systematic and random machine errors, or imperfections, such as jitter in magnet and radio-frequency power supplies, as well as translational and rotational magnet alignment errors. The beam responds in a self-c...

Individual particle orbits in a beam will respond to both external focusing and accelerating forces as well as internal space-charge forces. The external forces will reflect unavoidable systematic and random machine errors, or imperfections, such as jitter in magnet and radio-frequency power supplies, as well as translational and rotational magnet alignment errors. The beam responds in a self-c...

BACKGROUND Plain pneumococcal polysaccharide (PPS) booster administered during second year of life has been shown to cause hyporesponsiveness. We assessed the effects of PPS booster on splenic memory B cell responses and persistence of PPS-specific long-lived plasma cells in the bone marrow (BM). METHODS Neonatal mice were primed subcutanously (s.c.) or intranasally (i.n.) with pneumococcal c...

BACKGROUND Experience of hepatitis B vaccination in a contemporary renal replacement programme is reported. METHODS A total of 406 patients were involved: 214 on haemodialysis, 97 on continuous ambulatory peritoneal dialysis, 67 predialysis (serum creatinine >400 micromol/l), and 28 with a failing transplant. Primary vaccination comprised recombinant hepatitis B vaccine (Engerix B) 40 microg ...

We evaluated the safety and immunogenicity of two doses of a live-attenuated, tetravalent dengue virus vaccine (F17/Pre formulation) and a booster dose in a dengue endemic setting in two studies. Seven children (7- to 8-year-olds) were followed for 1 year after dose 2 and then given a booster dose (F17/Pre formulation), and followed for four more years (Child study). In the Infant study, 49 2-y...