Bone fracture healing is processed through multiple stages including the cartilaginous callus formation and its transition to bony callus. FGFR3 negatively regulates chondrogenesis and enhances osteogenesis during skeleton development. We previously found in mice carrying gain-of-function mutation of FGFR3 that FGFR3 delays the healing of un-stabilized fracture that heals mainly through endocho...

Bones are the principal structural components of a skeleton; they play unique roles in the body providing its shape maintenance, protection of internal organs and transmission of forces. Ultimately, their structural integrity is vital for the quality of life. Unfortunately, bones can only sustain loads until a certain limit, beyond which they fail. Understanding a fracture behaviour of bone is ...

OBJECTIVE We planned this study to evaluate the role of bone scintigraphy in patients with suspected carpal fracture and normal or suspicious radiographs following carpal injury. METHODS Three-phase bone scintigraphy using Tc-99m-MDP was performed on 32 patients with negative radiographs but clinically suspected fracture at two weeks after the trauma. Focally increased radiopharmaceutical upt...

Optimising the results of fracture treatment requires a holistic view of both patients and treatment. The nature of the patient determines the priority targets for outcome, which differ widely between the elderly and the young, and between the victims of high and low energy trauma. The efficacy of treatment depends on the overall process of care and rehabilitation as well as the strategy adopte...

We evaluated 100 consecutive patients with a suspected scaphoid fracture but without evidence of a fracture on plain radiographs using MRI within 24 hours of injury, and bone scintigraphy three to five days after injury. The reference standard for a true radiologically-occult scaphoid fracture was either a diagnosis of fracture on both MRI and bone scintigraphy, or, in the case of discrepancy, ...

Healing of the bone is different with the other part of the body. Fracture healing is actually a bone regeneration with no scar tissues, where as in wound healing, injured tissue is replaced by  connective tissue which became a scar, Traditionally fracture healing is divided in to 4 stages: 1) Stage of inflammation; 2) Stage of soft callus; 3) Stage of hard callus and 4) Stage of remodeling. In...

The authors report the case of a 28-year old male who presented with a compound diaphyseal fracture of the tibia, which was treated with intramedullary nailing. Postoperatively he required an extensive fasciotomy for an acute compartment syndrome. The fracture evolved towards post-traumatic osteomyelitis, growing methicillin-resistant Staphylococcus aureus (MRSA), combined with a large overlyin...

A total of 693 female U.S. Marine Corps recruits were studied with anthropometry and dual-energy X-ray absorptiometry (DXA) scans of the midthigh and distal third of the lower leg prior to a 12 week physical training program. In this group, 37 incident stress fracture cases were radiologically confirmed. Female data were compared with male data from an earlier study of 626 Marine recruits exten...

at neck region called as Trans cervical neck fracture. Third bone shows fracture that happens at intertrochanteric line of femur bone known as Intertrochanteric fracture. The fourth bone shows the fracture that happens at sub trochanteric region named as subtrochanteric fracture, Fracture that happens at greater trochanter region shown in fifth bone is known as fracture at greater trochanter, i...