An auditory discrimination paradigm was employed to elicit event-related brain potentials in 13 patients with Alzheimer's disease and 14 patients with multi-infarct dementia. The P300 latency was significantly prolonged in 12 patients with dementia compared with age-matched controls and showed a significant negative correlation with the score of Wechsler Adult Intelligence Scale (WAIS), especia...

The number of melanin containing nerve cells of the locus coeruleus and vagus nucleus is reduced in Alzheimer's disease by 60% with decrease of 22% in the protein synthetic capability of remaining cells. These changes are matched by reductions in brain noradrenaline in eight regions, averaging 36%. In multi-infarct dementia, however, all three of these features are unchanged. These findings ind...

PURPOSE The aim of this study was to investigate if ischemic stroke final infarction volume and location can be used to predict the associated functional outcome using a multi-class support vector machine (SVM). MATERIAL AND METHODS Sixty-eight follow-up MR FLAIR datasets of ischemic stroke patients with known modified Rankin Scale (mRS) functional outcome after 30 days were used. The infarct...

BACKGROUND AND PURPOSE Abnormal expression of some matrix metalloproteinases (MMP) has shown to play a deleterious role in brain injury in experimental models of cerebral ischemia. We aimed to investigate MMP-2 (gelatinase A) and MMP-9 (gelatinase B) in brain parenchyma in both ischemic and hemorrhagic strokes. METHODS Postmortem fresh brain tissue from 6 ischemic and 8 hemorrhagic stroke pat...

background: stroke is the third leading cause of invalidism and death in industrialized countries. there are conflicting reports about the effects of angiotensin ii on ischemia-reperfusion brain injuries and most data have come from chronic hypertensive rats. in this study, hypotensive and non-hypotensive doses of candesartan were used to investigate the effects of angiotensin ii at1 receptor b...

silent brain infarcts (sbi) are associated with an increased risk of subsequent stroke. sbi are incidentally revealed by ct or mri executed in stroke patients. a prospective study was undertaken involving 200 consecutive patients aged >45 years with brain infarct admitted in university of alberta hospital, canada (100 patients) and valie-asr hospital, iran (100 patients) in 2003. patients were ...

Background: The role of nitric oxide (NO) of endothelial or neuronal origins in cerebral ischemia and reperfusion injuries are far from being settled, extending from being important to not having any role at all.  Objective: To investigate the role of NO of endothelial and neuronal origins in ischemia/reperfusion injuries in focal cerebral ischemia, L-NAME, a non selective NO synthase inhibitor...

OBJECTIVES to compare the therapeutic effects of two approaches to gait re-training--a schedule of conventional physiotherapy and treadmill re-training--in patients with higher-level gait disorders associated with cerebral multiinfarct states. DESIGN single-blind crossover study involving a 4-week baseline period, 4 weeks of treadmill re-training and 4 weeks of conventional physiotherapy. S...

Three hundred and nine men with organic dementia, cerebral atrophy, or psycho-organic syndrome admitted for five nights or more to one of 18 Quebec hospitals were individually matched with patients admitted (1) with some other psychiatric diagnosis and (2) to a general hospital. Lifetime occupational histories were obtained by telephone. Occupational exposure to solvents was assessed blind to t...

INTRODUCTION The relationships between plasma levels of brain natriuretic peptide (BNP) and severity and location of stroke, prognosis, and infarct volume were investigated in acute ischemic stroke patients who presented within the first 24 hours (h) of stroke. MATERIAL AND METHODS Brain natriuretic peptide levels were tested in 40 patients and 30 healthy controls. Infarct volume was automati...