A recent analysis of the main causes of death in a consecutive series of 132 patients (96 deaths) with fulminant hepatic failure (F.H.F.) seen over a seven-year period showed cerebral oedema in 35 (31 %) of the 92 cases in which the brain was examined at necropsy. In 20 of these there was associated brain herniation, and in some cases death appeared to be due to cerebral oedema at a time when l...

When the cell surface molecule Fas is triggered by its agonist Fas ligand the result is apoptosis of these cells and tissue destruction. To elucidate the pathophysiological relevance of Fas ligand in patients with cerebral oedema caused by trauma, we examined its concentrations in cerebrospinal fluid in 18 patients using specific ELISA. Serum and cerebrospinal fluid from healthy people and inju...

INTRODUCTION A potentially lethal complication of diabetic ketoacidosis (DKA) in children is brain oedema, whether caused by DKA itself or by the therapeutic infusion of insulin and fluids. CASE PRESENTATION A 10-year old previously healthy boy with DKA became unconscious and apnoeic due to cerebral oedema (confirmed by abnormal EEG and CT-scan) during treatment with intravenous fluids (36 ml...

Sir, a potentially new sign in multiple sclerosis was described in Brain (Gelfland et al., 2012). This new sign, microcystic macular oedema, is intriguing because it is considered to indicate breakdown of the blood-retinal barrier with or without microglial inflammation (Gelfland et al., 2012). There are earlier reports on vascular instability and leakage during inflammation in multiple scleros...

Background and Aim: The purpose of the present study is to provide a basis for use Curcuma longa extract as therapeutic agent status epilepticus. Methods: effect on epilepticus in rat model was investigated. rat’s SE induced by pilocarpine evaluated through measurement seizure duration, brain oedema hippocampal oxidative stress this model. Results: In pre-treated with (400mg/kg) water content l...

BackgroundWhilst there has been progress in supportive treatment for traumatic brain injury (TBI), specific neuroprotective interventions are lacking. Models of ischaemic heart and show the therapeutic potential argon gas, but it is still not known whether inhaled (iAr) protective TBI. We tested effects acute administration iAr on oedema, tissue micro-environmental changes, neurological functio...

The aim of this study was to explore the spatiotemporal development of cerebral oedema in the early stage of severe burn (50% TBSA, third degree), using a four-dimensional (4D) mathematical model. Twenty-six male mongrel dogs were randomly divided into control and 6, 12, 18, and 24 post-burn hour (PBH) groups. The manifestation of magnetic resonance imaging (MRI) and histopathology, changes of ...