STUDY OBJECTIVES To evaluate the prevalence and natural history of sleepiness following traumatic brain injury. METHODS This prospective cohort study used the Sickness Impact Profile to evaluate sleepiness in 514 consecutive subjects with traumatic brain injury (TBI), 132 non-cranial trauma controls, and 102 trauma-free controls 1 month and 1 year after injury. RESULTS Fifty-five percent of...

Traumatic brain injury is the leading killer after trauma, in part because of coagulopathy. Factor VIIa may be a useful therapy in this setting, depending on the relative risk for thromboembolic complications. Kluger and coworkers recently conducted a retrospective review of patients with traumatic brain injury from a previous factor VIIa and trauma trial. It documents an encouragingly low rate...

over half of all reported traumatic brain injuries are the result of a motor vehicle accident. other then the direct head impact itself, the sheer forces of the accident can cause the brain also to collide against the internal bone of the skull. in fact, when a moving head comes to a quick stop, the brain continues in its movement, striking the interior of the skull. this can cause bruising of ...

Recent research in identification of brain injury after trauma shows many possible blood biomarkers that may help identify the fetus and neonate with encephalopathy. Traumatic brain injury shares many common features with perinatal hypoxic-ischemic encephalopathy. Trauma has a hypoxic component, and one of the 1st physiologic consequences of moderate-severe traumatic brain injury is apnea. Trau...

formula one legend michael schumacher hit his head severely while skiing on december 29, 2013. he was operated on for brain decompression and left in a coma fighting for life. in such severe brain injury with cerebral contusion and hemorrhage following head trauma, refractory to medical therapy and with increasing cerebral oedema and intracranial pressure, critically low cerebral perfusion can ...

Traumatic brain injury (TBI) is described by a disruption in the normal function of the brain due to an injury following a trauma, which can potentially cause severe physical, cognitive, and emotional impairment. The use of human stem cells and self-assembling peptide scaffolds suggest huge potential for application in the treatment of TBI. In the present study, we surveyed the beneficial effec...

Traumatic brain injury (TBI) is one of the major causes of disability in modern society. The World Health Organization has predicted that, by 2020, traffic accidents will represent the greatest burden of global disease and injury. Brain injury after trauma occurs in two stages. Primary injury is directly associated with the biomechanical effects of the trauma, whereas secondary injury occurs la...

this study was designed to develop a modified tbi weight drop model for induction of focal mild cerebral injury. a stereotaxic coupled weight drop device was designed. principle arm of device carries up to 500g weights which their force was conveyed to animal skull through a thin nail like metal tip. to determine the optimal configuration of the device to induce mild tbi, six different trials w...