Strychnine is one of the oldest poisons known to man. The source of this potent toxin is the Strychnos nux-vomica plant, which actually contains two distinct alkaloidsstrychnine and brucine. Although principally found in the seeds, these alkaloids can be isolated in varying concentrations from virtually all parts of the plant including the bark, leaves and roots[1]. Once consumed, strychnine pr...

OBJECTIVE To evaluate the pharmacokinetics and tissue distribution of liposomal brucine (LB) for dermal application. METHODS Pharmacokinetics and tissue distribution were studied by in vivo animal testing. High performance liquid chromatography (HPLC) was used to detect the concentration of brucine in rats' skin, plasma and various tissues. RESULTS After dermal administration, LB was absorb...

A simplified technic for the determination of serum protein-bound iodine (PBI) is presented. Endogenouslylabeled 1131 PBI is completely recovered. The technic is basedon the method of Barker et al. (1) and includes the following modifications: The number of washesof the precipitated serum proteins are decreased. Unashed iodide standards are used in a sodium carbonate solution rather than an int...

Strychnos nux vomica Linn.(Loganaceae) commonly known as Nux vomica (Kupeelu), is a poisonous plant and its seeds are used widely in Ayurvedic system of medicine since time immemorial. Ayurveda advocates that nux vomica seeds are to be administered in therapeutics only after going through certain purificatory measures (Shodhana). There are more than six media: cow's urine (Go mutra), cow's milk...

conclusions clinically, these results are logical because the required dose of alkaloids for treatment of diarrhea is lesser than the needed doses to treat addiction, arthralgia, and paralysis. results the first itm method reduced the strychnine level from 1.083 to 0.577 and brucine from 0.739 to 0.361. for the second and third itm methods, the levels of strychnine reached 0.838 and 0.812, and ...