Purpose: Our aim was to isolate a novel human miniantibody (scFv) that specifically targets ErbB2-positive cancer cells. ErbB2, a tyrosine kinase receptor, is overexpressed in clinically significant tumors, such as breast, ovary, and lung carcinomas. In normal tissues, it is expressed only in certain epithelial cell types. Experimental Design: A large phagemid library (Griffin.1 library) of hum...
