Objective Several studies have suggested the efficacy of bupropion and escitalopram on reducing the excessive internet game play. We hypothesized that both bupropion and escitalopram would be effective on reducing the severity of depressive symptoms and internet gaming disorder (IGD) symptoms in patients with both major depressive disorder and IGD. However, the changes in brain connectivity bet...

The characteristics of the interaction between reserpine and bovine serum albumin (BSA) were studied by fluorescence, UV-vis absorption and Fourier transform infrared (FT-IR) spectroscopy. Spectroscopic analysis revealed that fluorescence quenching of BSA by reserpine was through a static quenching procedure. The binding constant K(A) of reserpine with BSA at 293, 301 and 309 K was 1.63, 1.78 a...

Although the exact mechanism that makes bupropion hydrochloride (Zyban) effective as a smoking cessation aid has not been fully elucidated, studies have found that bupropion and nicotine share behavioural and neurophysiological properties suggesting that bupropion might serve as a substitute for nicotine. In fact, bupropion prompts nicotine-appropriate responding in operant and Pavlovian drug d...

A single injection of 100 micrograms reserpine into the crop of the medicinal leech, Hirudo medicinalis, reduced CNS serotonin and dopamine levels to less than 1% of control values within 3 d. High-pressure liquid chromotography- (HPLC) determined CNS serotonin and dopamine levels remained maximally depressed for approximately 1 month following reserpine injection. Subsequently, amine levels re...

killed 18 hr after administration of the labeled drug. Analysis of the various brain areas showed that with the exception of the cerebellum, residual E3H]reserpine concentrations were markedly iowered in all brain areas (Table 2), indicating that mutual ~eserpine-tetrabe~~ne sites are w~d~pread in the brain. The other way of establishing the specificity of reserpine binding was by taking advant...

Bupropion hydrochloride (HCI) is an antidepressant that acts as a norepinephrine and dopamine reuptake inhibitor and has three different dosage forms including immediate release (IR), sustained release (SR), and extended release (ER). Despite its relatively safe side effect profile bupropion may cause several side effects. Here, we aimed to report a case with major depression using extended rel...

A new, non-invasive method for measuring reserpine-induced tremor in rodents is described here. The test procedure is based on the piezo-electric principle and was evaluated using the tremorogenic compound reserpine and the stereotypies-inducing drug apomorphine. Whereas for reserpine an orderly and dose-related increase in activity was observed, no such effect was detected with apomorphine. In...

1. a. Reserpine is a risk factor. Overall, the incidence of breast cancer is 10.47 per 100,000 women-years in reserpine users and 6.14 per 100,000 women-years in nonusers. Moreover, among the non-obese, the rate ratio is: 6.40/4.10 = 1.6. Looking in the non-obese women avoids potential confounding by obesity if it is a risk factor. b. Obesity is also a risk factor. The overall incidence rates f...

attention-deficit/hyperactivity disorder is one of the most common mental disorders in childhood, and it continues to adulthood without proper treatment. stimulants have been used in the treatment of attention-deficit/hyperactivity disorder (adhd) for many years, and the efficacy of methylphenidate in the treatment of adults with adhd has been proven to be acceptable according to meta-analysis ...

conclusions these results provide empirical support for conducting a further study on comparing different add-on strategies for treating drug-induced sd. background antidepressant-induced sexual dysfunction (sd) is a common problem, associated with a significant risk of non-adherence. selective serotonin reuptake inhibitors (ssris) are associated with a substantial risk of sd. only 10 % of pati...