The absence of TSH-stimulated radioiodide uptake in differentiated thyroid cancer is associated with a high recurrence rate and reduced survival. We studied regulation of the sodium/iodide symporter gene in human papillary thyroid cancer cell lines (BHP) and primary human thyroid cells. BHP cells expressed very low levels of sodium/iodide symporter mRNA and did not concentrate iodide, but iodid...

Previous studies have demonstrated that short-term oral iodide administration, in doses ranging from 1500 micrograms to 250 mg/day, has an inhibitory effect on thyroid hormone secretion in normal men. As iodide intake in the USA may be as high as 800 micrograms/d, we investigated the effects of very low dose iodide supplementation on thyroid function. Thirty normal men aged 22-40 years were ran...

The energy profiles of various configurations the tetra-n-butylammonium ion (Bu 4 N + ) arising by changing angle between a pair butyl ligands, as well rotating alkyl fragments in gas phase, were calculated using DFT methods. A hypothesis about most probable way conformations ions during phase transitions highly conductive solid electrolytes was proposed.

introduction: effective debridement of the root canal system with chemical irrigants prior to obturation is the key to long-term success of endodontic therapy. the purpose of this study is to compare the antibacterial activity of 2.5% sodium hypochlorite (naocl) and 2% iodine potassium iodide (iki) solutions as intracanal disinfectant in infected root canals during one-visit endodontic treatmen...

an experiment was conducted to investigate the effect of thyroid gland activity modulation (hyper or hypothyroidism) on energy utilization in broiler chickens. two hundred and forty one-day-old cobb broiler chicks were distributed into three dietary metabolizable energy (me) treatment groups (80 chicks each). the control group (e0) was fed basal diet (3150 kcal/kg diet), the second group (e1) w...

Thyroid hormones are essential for normal development and metabolism. Thyroid hormone biosynthesis requires iodide uptake into the thyrocytes and efflux into the follicular lumen, where it is organified on selected tyrosyls of thyroglobulin. Uptake of iodide into the thyrocytes is mediated by an intrinsic membrane glycoprotein, the sodium-iodide symporter (NIS), which actively cotransports two ...

The efficiency and selectivity of hydrogen atom transfer from organic molecules are often difficult to control in the presence of multiple potential hydrogen atom donors and acceptors. Here, we describe the mechanistic evaluation of a mode of catalytic activation that accomplishes the highly selective photoredox α-alkylation/lactonization of alcohols with methyl acrylate via a hydrogen atom tra...