It is still unclear what molecular forces drive chaperone-mediated protein folding. Here, we obtain a detailed mechanistic understanding of the forces that dictate the four key steps of chaperone-client interaction: initial binding, complex stabilization, folding, and release. Contrary to the common belief that chaperones recognize unfolding intermediates by their hydrophobic nature, we discove...

introduction knowledge is continuously being produced in the process of formulating and implementing rural development projects. the capital is available without any cost, but it is neglected. knowledge has been distributed along the extensive network through the country. if knowledge management is recorded and exploited, it could lead to dramatic changes as a result of the butterfly approach. ...

Drinking and driving is a significant health risk behavior for adolescents. This study tested mechanisms by which disinhibited personality traits (impulsivity and sensation seeking) and aspects of the adolescent home/social environment (parental monitoring and alcohol accessibility) can influence changes in drinking and driving behavior over time. Two hundred two high school age youths were ass...

Bayesian networks (BNs) are advantageous when representing single independence models, however they do not allow us to model changes among the relationships of the random variables over time. Due to such regime changes, it may be necessary to use di↵erent BNs at di↵erent times in order to have an appropriate model over the random variables. In this paper we propose two extensions to the traditi...

the aim of this study is to evaluate the obstacles due to a dpsir model combined with fuzzy analytic hierarchy process technique. hence, to prioritize the responses regarding the driving forces, pressures, states and impacts, the hierarchy of the model is established. evaluations and prioritization of model results of urban transport situation in tehran have provided a number of necessary issue...