OBJECTIVE To evaluate whether activated partial thromboplastin time (APTT) could be used in the laboratory diagnosis of hereditary or acquired angioedema (HAE or AAE) with and without C1 inhibitor (C1-INH) deficiency. METHODS In a prospective investigation, APTT and other coagulation parameters were determined in 149 adult patients with various types of angioedema and in 26 healthy participan...

The serpin C1 inhibitor (C1-INH) is the only regulator of classical complement activation as well as the major regulator of the contact system. Its importance is demonstrated by hereditary angioedema (HAE), a severe disease with potentially life-threatening attacks due to deficiency or dysfunction of C1-INH. C1-INH replacement is the therapy of choice in HAE. In addition, C1-INH showed to have ...

Let C1 and C2 be strong amalgamation classes of finite structures, with disjoint finite signatures σ and τ . Then C1∧C2 denotes the class of all finite (σ∪τ)-structures whose σ-reduct is from C1 and whose τ -reduct is from C2. We prove that when C1 and C2 are Ramsey, then C1 ∧ C2 is also Ramsey. We also discuss variations of this statement, and give several examples of new Ramsey classes derive...

BACKGROUND Hereditary angioedema (HAE) is a rare disease caused by C1-esterase inhibitor (C1-INH) deficiency, characterized by periodic attacks of acute edema affecting subcutaneous (SC) tissues and mucous membranes. Human C1-INH concentrate given intravenously (IV) is effective and safe, but venous access may be difficult. We compared SC and IV administration of human pasteurized C1-INH concen...

C1-inhibitor is the only known inhibitor of the classical pathway of complement and the major inhibitor of the contact pathway of coagulation. Like other serine proteinase inhibitors, C1-inhibitor can exist in three conformations, ie, the native, the proteinase-complexed, and the proteolytically inactivated form. Here we studied the plasma elimination kinetics of these three forms of human C1-i...

Study Design Retrospective cohort. Objective To clarify the sensitivity of C3-C2 spinolaminar line test as a screening tool for the stenosis of C1 space available for the cord (SAC). Methods Spine clinic records from April 2005 to August 2011 were reviewed. The C1 SAC was measured on lateral radiographs, and the relative positions between a C1 posterior arch and the C3-C2 spinolaminar line were...

We measured the relative positions between two pairs of compact extragalactic sources (CESs), J1925-2219 \& J1923-2104 (C1--C2) and J1928-2035 (C1--C3) on 2020 October 23--25 2021 February 5 (totaling four epochs), respectively, using Very Long Baseline Array (VLBA) at 15 GHz. Accounting for deflection angle dominated by Jupiter, as well contributions from Sun, planets other than Earth, Moon Ga...