نتایج جستجو برای: c4 complement

تعداد نتایج: 80191  

Journal: :The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 2012
Mehmet Sait Buğdaci Cetin Karaca Canan Alkim Beşir Kesıcı Banu Bayraktar Mehmet Sökmen

BACKGROUND/AIMS Hepatitis C virus leads to chronic liver disease, cirrhosis and hepatocellular cancer. Viral markers and other laboratory tests used in the diagnosis and follow-up of chronic hepatitis C do not correlate well with disease activity and liver histopathology. Therefore, alternative tests that indicate disease activity and relate with liver biopsy findings are needed. We aimed to in...

Journal: :Molecular immunology 2004
Michael C Carroll

Early studies of animals bearing natural deficiencies in complement C3 and C4 and mice transiently deficient in C3 suggested that the complement system played a role in humoral immunity. Identification and characterization of the complement receptors CD21 and CD35 and their expression on B lymphocytes provided evidence for a direct role for complement in "linkage of innate and adaptive immunity...

Journal: :Journal of clinical pathology 1979
I N Ross R A Thompson R D Montgomery P Asquith

Levels of the serum complement components, C3 and C4, in patients with Crohn's disease, ulcerative colitis, and miscellaneous gastrointestinal disorders were compared with those of normal blood donors. Significant increases of both components were found in all three patient groups, the highest being in patients with Crohn's disease. Generally, levels of C3 and C4 were lower in patients with ina...

Journal: :Human reproduction 2006
Mayumi Sugiura-Ogasawara Kyoko Nozawa Tamao Nakanishi Yukio Hattori Yasuhiko Ozaki

BACKGROUND The clinical significance of complement is unclear in patients with unexplained recurrent miscarriage, though low levels of complement 3 (C3) and/or complement 4 (C4) are reported to be associated with the antiphospholipid syndrome (aPS). We therefore investigated whether C3 and C4 have a predictive value for subsequent miscarriages. METHODS In total, 215 patients with a history of...

2010
Panisadee Avirutnan Anja Fuchs Richard E. Hauhart Pawit Somnuke Soonjeon Youn Michael S. Diamond John P. Atkinson

The complement system plays an essential protective role in the initial defense against many microorganisms. Flavivirus NS1 is a secreted nonstructural glycoprotein that accumulates in blood, is displayed on the surface of infected cells, and has been hypothesized to have immune evasion functions. Herein, we demonstrate that dengue virus (DENV), West Nile virus (WNV), and yellow fever virus (YF...

2017
Lingjun Zhang Brent A. Bell Yan Li Rachel R. Caspi Feng Lin

In addition to its conventional roles in the innate immune system, complement has been found to directly regulate T cells in the adaptive immune system. Complement components, including C3, C5, and factor D, are important in regulating T cell responses. However, whether complement component C4 is involved in regulating T cell responses remains unclear. In this study, we used a T cell-dependent ...

Journal: :Singapore medical journal 2007
P E J Chang C L Cheng K Asok K Y Fong S P Chee C K Tan

Visual disturbances in dengue infection are uncommon but may result in permanent visual impairment. We report a 32-year-old Chinese woman with dengue infection and she developed retinal haemorrhage, retinal vasculitis and macular detachment. Autoimmune screen revealed a low C4 complement level, possibly due to partial C4 complement deficiency. The patient was treated with steroids and there was...

2005
Alastair Frazer

Levels of the serum complement components, C3 and C4, in patients with Crohn's disease, ulcerative colitis, and miscellaneous gastrointestinal disorders were compared with those of normal blood donors. Significant increases of both components were found in all three patient groups, the highest being in patients with Crohn's disease. Generally, levels of C3 and C4 were lower in patients with ina...

Journal: :iranian journal of allergy, asthma and immunology 0
faegheh alizadeh najjarbashi mofid children hospital, school of medicine, shahid beheshti university of medical sciences, tehran, iran mehrnaz mesdaghi department of immunology, mofid children hospital, school of medicine, shahid beheshti university of medical sciences, tehran, iran and pediatric infections research center, mofid children hospital, shahid beheshti university of medical sciences, tehran, iran mohammadreza alaei department of endocrinology and metabolism, mofid children hospital, school of medicine, shahid beheshti university of medical sciences, tehran, iran marjan shakiba department of endocrinology and metabolism, mofid children hospital, school of medicine, shahid beheshti university of medical sciences, tehran, iran aliakbar jami department of pediatric cardiology, school of medicine, army university, tehran, iran farah ghadimi department of immunology, mofid children hospital, school of medicine, shahid beheshti university of medical sciences, tehran, iran

patients with organic acidemia are prone to different infections, which lead to acidosis episodes. some studies have evaluated the status of immune system in acidotic phase in these patients, but to the best of our knowledge no study has evaluated the immune system in non-acidotic phase of the disease. in this study, thirty-one patients with organic acidemia were enrolled. for evaluation of hum...

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