Biologics have transformed the management of moderate-to-severe psoriasis; however, none are curative, and an increasing number patients failed all available classes. MSCs, multipotent stem cells with immunomodulatory properties been used to treat immune-mediated inflammatory diseases including rheumatoid arthritis Crohn disease. We investigated efficacy safety umbilical cord-derived MSCs in 2 ...

Two new Zn4L6 cages composed of diamine subcomponents containing either naphthalene diimide (NDI) or porphyrin moieties are described. Their structural differences allow these cages to exhibit distinct interactions with different chemical stimuli, yielding different supramolecular products. The electron-poor NDI subunits of the first cage were observed to thread through electron-rich aromatic c...

Human ovarian carcinoma cells (C70 and C200) made resistant to cisplatin from A2780 cells demonstrated an approximately 20-fold resistance to the drug. These same cell lines showed no collateral resistance (as compared with the wild-type) to a novel glutathione S-transferase pi-activated prodrug [gamma-glutamyl-alpha-amino-beta[2-ethyl-N,N,N',N'-tetrakis (2-chloroethyl) phosphorodiamidate]-sulf...

New molecular complexes of fullerenes C60 and C70 with tetraphenylporphyrins [M(tpp)] in which M-H2, MnII, CoII, CuII, ZnII and Fe(III)Cl, have been synthesised. Crystal structures of two C60 complexes with H2TPP, which differ only in the number of benzene solvated molecules, and C60 and C70 complexes with [Cu(tpp)] have been studied. The fullerene molecules form a honeycomb motif in H2TPP.2C60...

We review the recent theoretical treatment of fullerenes as π-conjugated systems. Polaronic properties due to the Jahn-Teller type effects are mainly discussed. (1) A Su-Schrieffer-Heeger type electron-phonon model is applied to fullerenes: C60 and C70, and is solved with the adiabatic approximation to phonons. When the system (C60 or C70) is doped with one or two electrons (or holes), the addi...

We investigated curvature-enhanced spin-orbit coupling (SOC) and spinterface effect in carbon-based organic spin valves (OSVs) using buckyball C60 and C70 molecules. Since the naturally abundant (12)C has spinless nuclear, the materials have negligible hyperfine interaction (HFI) and the same intrinsic SOC, but different curvature SOC due to their distinct curvatures. We fitted the thickness de...

We present a solid-state NMR study of H2 molecules confined inside the cavity of C70 fullerene cages over a wide range of temperatures (300 K to 4 K). The proton NMR spectra are consistent with a model in which the dipole-dipole coupling between the ortho-H2 protons is averaged over the rotational/translational states of the confined quantum rotor, with an additional chemical shift anisotropy δ...

We have found that compounds formed between fullerenes and RuO4 can be hydrolyzed to the corresponding diols. RuO4 is easily prepared by the reaction of NaIO4 with RuO2 hydrate and subsequent extraction into CCl4. Due to a very low solubility of C60 or C70 in CCl4 we chose 1,2,4trichlorobenzene (TCB) as a main component of the reaction medium. TCB is an excellent solvent for C60 or C70 and is a...

Solution-processed organic field-effect transistors (OFETs) have attracted great interest due to their potential as logic devices for bendable and flexible electronics. In relation n-channel structures, soluble fullerene semiconductors been widely studied. However, they not yet met the essential requirements commercialization, primarily because of low charge carrier mobility, immature large-sca...