OBJECTIVES To identify common genetic variants that predispose to caffeine-induced insomnia and to test whether genes whose expression changes in the presence of caffeine are enriched for association with caffeine-induced insomnia. DESIGN A hypothesis-free, genome-wide association study. SETTING Community-based sample of Australian twins from the Australian Twin Registry. PARTICIPANTS Aft...

the purpose of this study was to investigate the effect of caffeine ingestion on anaerobic power; fatigue index and blood lactate levels in boys athlete students. among voluntarers 16 subjects were selected and devided into two caffeine and placebo groups in a simple – randomized manner base on fatigue index in the pretest. they were asked to prevent from doing intensified activities 24 hours p...

purpose the purpose of the present study was to evaluate the ergogenic effect of caffeine ingestion on mood state, simple reaction time, and muscle power during the wingate test recorded in the morning on elite judoists. methods twelve elite judoists (age: 21.08 ± 1.16 years, body mass: 83.75 ± 20.2 kg, height: 1.76 ±6.57 m) participated in this study. mood states, simple reaction time, and mus...

The isometric tension and membrane potential of single skeletal muscle fibres from the flexor muscle of the carpopodite in the meropodite of crayfish Procambarus clarkii (Girard) were studied to determine whether crayfish muscle contraction requires Ca2+ release from the sarcoplasmic reticulum. Contraction elicited by brief extracellular electrical stimulation was reduced by the removal of Ca2+...

SCOPE To elucidate the morphological and biochemical in vitro effects exerted by caffeine, taurine, and guarana, alone or in combination, since they are major components in energy drinks (EDs). METHODS AND RESULTS On human neuronal SH-SY5Y cells, caffeine (0.125-2 mg/mL), taurine (1-16 mg/mL), and guarana (3.125-50 mg/mL) showed concentration-dependent nonenzymatic antioxidant potential, decr...

In rings of rabbit facial vein (RFV), depletion of sarcoplasmic reticulum (SR) Ca2+ by caffeine abolished the subsequent isometric contraction to 25 mM K+ physiological salt solution (25K-PSS). However, the associated steady-state increase of smooth muscle intracellular free Ca2+concentration ([Ca2+]i), measured using fura PE3 and cuvette photometry, was not altered. Treatment with the specific...

Background and Objective: Today, obesity is one of the most important health problems in the world. The purpose of this study was to determine the effects of caffeine and high fat diet on expression of PGC1-α, Fndc-5 and UCP-1 genes in male Wistar rats. Materials and Methods: To study the aim of this survey, 40 male Wistar rats were divided into four equal groups (n=10 in each group), includin...

background: iranian (lahijan) black tea caffeine has been previously shown to have antifungal activity against candida albicans. the aim of this study was to investigate whether the combination of caffeine and fluconazole (flu) has an effective antifungal activity on a flu-resistant (mic >64mgl-1) c. albicans ptcc5027. materials and methods: caffeine from lahijan black tea was extracted and its...