Introduction Coffee contains a variety of different substances of which several are biological active (1). The physiological effect of coffee is normally linked to the content of caffeine (2). Coffee contains, however, also a considerable amount of chlorogenic acid (CGA) (3), which belongs to the important group of biologically active phenols of which 5-caffeoylquinic acid (5-CQA) is the most i...

Three new glucosylated caffeoylquinic acid isomers (1-3), along with six known compounds, have been isolated from an aqueous extract of the flower buds of Lonicera japonica. Structures of the new compounds were determined by spectroscopic and chemical methods as (-)-4-O-(4-O-β-d-glucopyranosylcaffeoyl)quinic acid (1), (-)-3-O-(4-O-β-d-glucopyranosylcaffeoyl)quinic acid (2), and (-)-5-O-(4-O-β-d...

in chlorogenic acid (5-caffeoylquinic acid) (Fig 1). Coffee, one of the most widely consumed beverages in the world, is the major dietary source of chlorogenic acids. Chlorogenic acid has antioxidant properties as shown by its ability to scavenge various free radicals when tested in vitro (3-5). Moreover, chlorogenic acid reduces glucose uptake by favouring the dissipation of the Na+ electroche...

Arabica and Robusta coffee beans were roasted at 220 ± 10°C for 7, 9 and 11 min to identify chemical descriptors in the beverages. The pH of the beverages showed the lowest value in the medium roasting level. In each degree of browning, the soluble solids content remained slightly higher in Arabica drinks. The contents of caffeine did not vary, but trigonelline decreased with burning up intensi...

The formation of acrylamide in model Maillard reaction systems containing phenolic compounds was examined, with regards to phenolic type, concentration, and model system matrix. In dry glyoxal/asparagine waxy maize starch (WMS) systems, 9 out of 10 examined phenolics demonstrated an inhibiting effect, with the most significant reductions (55-60%) observed for caffeoylquinic acids. In WMS glucos...

Abstract We have purified a novel caffeoylquinic acid named 3,4-di- O -caffeoylquinic isobutyl ester from the flower buds of Lonicera japonica Thunb., Caprifoliaceae. However, biological function is still unknown. Here, we found that effectively inhibited proliferation and migration hepatocellular carcinoma cells, it displayed less toxicity to normal liver cell line. Mechanistic studies showed ...

The inhibition of dipeptidyl peptidase-IV (DPPIV) is a popular route for the treatment of type-2 diabetes. Commercially available gliptin-based drugs such as sitagliptin, anagliptin, linagliptin, saxagliptin, and alogliptin were specifically developed as DPPIV inhibitors for diabetic patients. The use of Gynura bicolor in treating diabetes had been reported in various in vitro experiments. Howe...

Artemisia annua hot water infusion (tea) has been used in in vitro experiments against P. falciparum malaria parasites to test potency relative to equivalent pure artemisinin. High performance liquid chromatography (HPLC) and mass spectrometric analyses were employed to determine the metabolite profile of tea including the concentrations of artemisinin (47.5±0.8 mg L(-1)), dihydroartemisinic ac...

Blocking the polyol pathway plays an important role preventing diabetic complications. Therefore, aldose reductase (AR) and advanced glycation endproducts (AGEs) formation has significant effect on diabetic complications. Artemisia iwayomogi has long been used as treatment of various diseases in Korea. However, no literatures have reported on AR and AGEs formation inhibitory activities of A. iw...

Dorema glabrum Fisch. & C.A. Mey. (Apiaceae) is a monocarpic perennial plant distributed in southern Caucasus. In Azerbaijan Republic folk medicine, the gum-resin of this species is used as a diuretic and anti-diarrheal agent. It is also traditionally used for the treatment of bronchitis and catarrh. In the present study, chemical constituents of the essential oil and extract of D. glabrum aeri...