structural and magnetic properties of purine and pyrimidine nucleotides (cmp, ump, dtmp, amp, gmp, imp) were studied at different levels of ab initio molecular orbital theory. these calculations were performed at the hartree-fock level and density functional b3lyp methods. geometries were fully optimized by following cs symmetry restrictions. the standard 6-31g** basis set which includes polari...

specific elements (cr, al, ca, and si) and loss on ignition (loi) were used for semi-quantitative determination of the normative mineralogical composition of naturally occurring chromium ores in ophiolite complexes. by far the occurring ore minerals are complex both from the mineralogical and chemical viewpoints. the secondary minerals serpentine and cr-containing chlorite (kaemmererite) form n...

since there is no detailed hospital based incident reporting system, this study was designed to evaluate the medication errors associated with infusion pumps in intensive care unit (icu). the investigation was conducted in a teaching hospital in the form of a prospective, observational study. a sample size of 43 doses administered to icu patients was chosen to enable reliable estimate of error ...

purpose: in the present study we have tried to find the most reliable intraocular lens (iol) power calculation formula in patients with keratoconus (kcn) and cataract. methods: in a prospective case series between october 2010 and march 2012, eligible patients with cataract and kcn underwent phacoemulsification with iol implantation. preoperatively, based on iol master keratometric data iol pow...

The false discovery proportion FDP , the proportion of incorrect rejections among all rejections, is a direct measure of abundance of false positive findings in multiple testing. Many methods have been proposed to control FDP, but they are too conservative to be useful for power analysis. Study designs for controlling the mean of FDP, which is false discovery rate, have been commonly used. Howe...

The Elmore delay is the metric of choice for performancedriven design applications due to its simple, explicit form and ease with which sensitivity information can be calculated. However, for deep submicron technologies, the accuracy of the Elmore delay is insufficient. In this paper, we formulate a delay model using a provably stable two pole waveform response that provides a unique mapping be...

BACKGROUND Although randomized clinical trials (RCTs) are considered the gold standard of evidence, their reporting is often suboptimal. Trial registries have the potential to contribute important methodologic information for critical appraisal of study results. METHODS AND FINDINGS The objective of the study was to evaluate the reporting of key methodologic study characteristics in trial reg...

In the clinical trial designing stage, trial statisticians need to provide a reference sample size for conducting the trial. In general, this task could be completed by forming the main research question into a statistical procedure and then implementing the published formulae or software, such as n-query and STATA, to make the calculation. When more complex statistical procedures are involved ...

Understanding the concept of extrapolation of dose between species is important for pharmaceutical researchers when initiating new animal or human experiments. Interspecies allometric scaling for dose conversion from animal to human studies is one of the most controversial areas in clinical pharmacology. Allometric approach considers the differences in body surface area, which is associated wit...