UNLABELLED BACKGROUND Calendula officinalis L. (pot marigold) is an annual aromatic herb with yellow or golden-orange flowers, native to the Mediterranean climate areas. Their seeds contain significant amounts of oil (around 20%), of which about 60% is calendic acid. For these reasons, in Europe concentrated research efforts have been directed towards the development of pot marigold as an oi...

conclusions therefore, our results suggest that although administration of 300 mg/kg of calendula officinalis extract showed salutary effects on anti-oxidant profile, yet its protective effects on anti-diabetic and regenerative properties on nephropathy were ambiguous and require more investigations. background chronic hyperglycemia leads to microvascular and macrovascular complications such as...

Calendula officinalis is an annual herb from Mediterranean origin which is popularly used in wound healing and as an anti-inflammatory agent. In this study, the ethanolic extract, the dichloromethane, and hexanic fractions of the flowers from plants growing in Brazil were produced. The angiogenic activity of the extract and fractions was evaluated through the chorioallantoic membrane and cutane...

Two homologous cDNAs, CoFad2 and CoFac2, were isolated from a Calendula officinalis developing seed by a polymerase chain reaction-based cloning strategy. Both sequences share similarity to FAD2 desaturases and FAD2-related enzymes. In C. officinalis plants CoFad2 was expressed in all tissues tested, whereas CoFac2 expression was specific to developing seeds. Expression of CoFad2 cDNA in yeast ...

Model studies of the influence lectin-containing extracts medicinal plants St. John's wort (Hypericum perforatum L.), common yarrow (Achillea millefolium marigold (Calendula officinalis L.) and dwarf evergreen (Helichrysum arenarium (L.) Moench.) on growth development wheat, oat, barley rye at beginning their ontogenesis. They testify to specificity action in relation model objects, which is pr...

The role of the aldose reductase in type 2 diabetes is widely described. Therefore, it is of interest to identify plant derived compounds to inhibit its activity. We studied the protein-ligand interaction of 267 compounds from different parts of seven plants (Allium sativum, Coriandrum sativum, Dacus carota, Murrayyakoneigii, Eucalyptus, Calendula officinalis and Lycopersicon esculentum) with a...

three major flavonoid fractions were separated from a methanol extract of calendula officinalis flowers by preparative tlc. these fractions were evaluated for the inhibition of parent and tamoxifen resistant t47d human breast cancer cells. we also examined the effect of quercetin and isorhamnetin on the growth of parent and resistant t47d cells in the presence and absence of tamoxifen. it was f...