OBJECTIVE Moldable in situ self-stabilizing and hardening bone graft materials facilitate handling and may be suitable for membrane-free bone regeneration methods. This study aimed to compare two moldable synthetic calcium phosphate materials in a rabbit calvarial defect model. METHOD In 12 New Zealand white rabbits, four evenly distributed 6 mm diameter defects were drilled in the calvarial ...

Beta-tricalcium phosphate ( β -TCP) and hydroxyapatite (HA) are widely used as bone graft extenders due to their osteoconductivity and high bioactivity. This study aims to evaluate the possibility of using porous substrate with composite ceramics ( β -TCP: HA = 60% : 40%, 60TCP40HA) as a bone graft extender and comparing it with Bio-Oss. Interconnectivity and macroporosity of β -TCP porous subs...

METHODS: Custom 3DPBC scaffolds designed to present lattice-based porosity only towards the dural surface were either coated with collagen (control) or coated with collagen and immersed in a 100 μM concentration dipyridamole (DIPY) solution. Sheep (n=5) were subjected to 2 ipsilateral trephine-induced (11 mm diameter) calvarial defects. Either a control or a DIPY scaffold was placed in each def...

METHODS: Custom 3DPBC scaffolds designed to present lattice-based porosity only towards the dural surface were either coated with collagen (control) or coated with collagen and immersed in a 100 μM concentration dipyridamole (DIPY) solution. Sheep (n=5) were subjected to 2 ipsilateral trephine-induced (11 mm diameter) calvarial defects. Either a control or a DIPY scaffold was placed in each def...

This paper presents rapid prototyping and reverse engineering techniques applied to create an implant for the surgical reconstruction of a large cranial defect. A series of computed tomography (CT) images was obtained and purpose built software was used to extract the cranial geometry in a point cloud. The point cloud produced was used for: (a) the creation of a stereolithographic (STL) physica...

381 including infection and allergic reaction, and its use should definitely be avoided in the case of children, whose bones have not yet stopped growing. In the case of the sixteen-year-old patient in this study, while alloplastic cranioplasty was possible, as the growth of the skull bone was nearly complete, the patient and his guardian decided upon autologous cranioplasty. In cases of large ...

Neurofibroma of the scalp are mostly multiple as part of neurofibromatosis or other phakomatosis. De novo solitary types are less common and rarely erode the skull, unlike the intracranial counterpart. Skull erosion has been reported in adults with longstanding plexiform neurofibromas. We report a giant neurofibroma on the scalp of a five-year-old boy, managed in our center. Although this condi...

Aplasia cutis congenita is a disease in which skin, bone, and dura mater can be absent. In majority of the cases it affects the scalp. We report a baby girl born at term with a large scalp and skull defect measuring 9 × 10 cm. Conservative treatment led to complete epithelization.

Large-area craniofacial defects remain a challenge for orthopaedists, hastening the need to develop facile and safe tissue engineering strategy; osteoconductive material combination of optimal growth factors microenvironment should be considered. Faced with unmet need, we propose that abundant cytokines chemokines can secreted from bone defect, provoking infiltration endogenous stem cells assis...