Engineered calmodulins (CaMs), rendered Ca2+-insensitive by mutations, function as dominant negatives in heterologous systems, and have revealed mechanisms of ion channel modulation by Ca2+/CaM. The use of these CaMs in native mammalian cells now emerges as a strategy to unmask the biology of such Ca2+ feedback. Here, we developed recombinant adenoviruses bearing engineered CaMs to facilitate t...

after springs production, different residual stresses are created in the inner and outer surfaces of spring wires. some of these stresses for example compressive residual stresses are useful and some are harmful. the effects of vareation of these stresses are caused spring relaxation and decrising in their free length when they are loaded intermittently. for review this phenomena in this resear...

The Arabidopsis genome harbors seven calmodulin (CAM) and 50 CAM-like (CML) genes that encode potential calcium sensors. The CAMs encode only four protein isoforms. Selective pressure to maintain multiple CAMs indicates nonredundancy. Sequence divergence, even in the EF hand calcium-binding motif, exists among the CMLs and, therefore, divergent functions are likely to have evolved. Expression d...

During development, axons elongate along the correct path toward their final targets. Growing axons maintain adhesive interactions with specific environmental cues via cell adhesion molecules (CAMs). The axon-environment adhesion must be dynamically controlled, both temporally and spatially, to enable the axons to navigate and migrate correctly. In this way, CAMs play a central role in mediatin...

Case of cerebrofacial arteriovenous metameric syndrome (CAMS) in a 9-year-old boy is described with arteriovenous malformation simultaneously involving the brain and face, with characteristic CAMS type 1 and 2 involvement. This patient demonstrates the wide spectrum of clinical manifestations of CAMS, and in this particular case, the patient exhibits features of hypopituitarism-an association t...

BACKGROUND Complementary and alternative medicines (CAMs) are being used increasingly across the world. In Australia, community pharmacists are a major supplier of these products but knowledge of the products and interactions with other medicines is poor. Information regarding the use of CAMs by metropolitan pharmacists has been documented by the National Prescribing Service (NPS) in Australia ...

BACKGROUND The aim of this study was to determine the prevalence of complementary and alternative medicine (CAM) use among patients presenting to a head and neck oncology clinic prior to a diagnosis. METHODS The study was conducted by administering questionnaires to 102 patients after being seen in the Head and Neck Oncology clinic for their initial consultation. The questionnaire assessed th...

Autonomous mobile programs (AMPs) offer a novel decentralised load management technology where periodic use is made of cost models to decide where to execute in a network. In this paper we demonstrate how sequential programs can be automatically converted into AMPs. The AMPs are generated by an automatic continuation cost analyser that replaces iterations with Costed Autonomous Mobility Skeleto...