background: chemokine receptors have been shown to play an important role in the development and metastatic spread of various malignancies. in this study, the gene expression profile of some key chemokine receptors involved in metastasis has been investigated in esophageal and breast cancer cell lines.   methods: in a descriptive study, gene expression profile of ccr1, ccr6, ccr7, ccr9, cxcr1, ...

the anti-cancer activity of metal ions in the lanthanide group is being considered recently. it has been reported that cerium salts might stimulate the metabolism and therefore, produce anti-cancer effects. however, little is known about the effects of protein-cerium complex in controlling cancer cell growth. the aim of the present study was to elucidate the possible pathways for the cytotoxic ...

background breast cancer is the most common malignancy in women around the world so finding new biomarkers for early detection and also study on molecular aspects of breast cancer is valuable. cancer testis genes are a group of genes expressed solely in testis and in a range of human malignancies. objectives in this study we determined the expression of cancer testis genes tsga10, tex101 and od...

cancer is a group of diseases characterized by uncontrolled proliferation of abnormal cells. because of the severe side effects and resistance to the traditional chemotherapeutic agents, the necessity for discovery of new anticancer drugs is a crucial topic. in the present study we synthesized new derivatives of 2-(4-fluorophenyl)- n -halophenylacetamide and assessed their cytotoxicity against ...

background gastric cancer is the second most common cause of cancer death worldwide. lentinan was shown to induce apoptosis in gastric cancer cells and could be used for the treatment of gastric cancer. objectives in this study, we analyzed anticancer effect of lentinan, a fungal β-glucan, on the gastric adenocarcinoma cell line (ags). materials and methods we used the dna ladder and tunnel app...

background: opticin, as a member of small leucine rich proteoglycans (slrps), mainly expressed in human eyes. it is also expressed in human brain, ligament, liver and skin, but at lower levels than the eyes. in the present study, expression of opticin was studied in a variety of human cancer cell lines. materials and methods: in this basic study, human cancer cell lines including, a-172 (brain ...

Background: Lactoferrin (Lf) is a glycoprotein, a member of the transferrin family.From ten known mechanisms of anti-cancer chemoperotecive compounds, Lf alone, has six of these functions and inhibits cancer. In this study, the effect of lactoferrin purified from bovine colostrum was studied as an anti-cancer agent on esophageal cancer cell line. Materials and Methods: Bovine colostrum were ...

psa is a 33-kda serine protease that is produced predominantly by prostate epithelium. however, it has been shown that about 30-40% of female breast tumors produce psa and its production is associated with the presence of estrogen and progesterone receptors. we have now developed a new tissue culture system to study psa production in breast cancer and its association with prognostic factors suc...

Objective(s): Berberine is one of the main alkaloids and it has been proven to have different pharmacological effects including inhibition of cell cycle and progression of apoptosis in various cancerous cells; however, its effects on cancer metastasis are not well known. Cancer cells obtain the ability to change their chemokine system and convert into metastatic cells. In this study, we examine...

The lung cancer is one of the most dangerous cancers and is also the leading cause of cancer death worldwide, accounting for about 1.3 million deaths annually. However in clinical practice, lung cancer therapies commonly do with chemotherapy, although it is hard because the lung cancer may progress to metastasis stage. The metastasis of lung cancer is highly dependent of expression of matrix me...