1Division of Hepatology and Liver Research, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Groote Schuur Hospital, Western Cape, South Africa. 2Division of Rheumatology, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Groote Schuur Hospital, Western Cape, South Africa. Received date: 14 Nov 2016; Accepted date: 12 Dec 2016; Published da...

Background. Caffeic acid phenethyl ester (CAPE) has been reported to possess time-dependent fibrinolytic activity by in vitro assay. This study is aimed at investigating fibrinolytic dose-dependent activity of CAPE using in vitro assays. Methods. Standardized human whole blood (WB) clots were incubated in either blank controls or different concentrations of CAPE (3.75, 7.50, 15.00, 22.50, and 3...

Breast cancer is the second leading cause of death amongst women worldwide. As a result, many have turned their attention to new alternative approaches to treat this disease. Caffeic acid phenylethyl ester (CAPE), a well-known active compound from bee propolis, has been previously identified as a strong antioxidant, anti-inflammatory, antiviral and anticancer molecule. In fact, CAPE is well doc...

We investigated the mechanisms by which caffeic acid phenethyl ester (CAPE), a phenolic antioxidant, inhibited the stimulation of prostaglandin (PG) synthesis in cultured human oral epithelial cells and in an animal model of acute inflammation. Treatment of cells with CAPE (2.5 microg/ml) suppressed phorbol ester (12-O-tetradecanoylphorbol-13-acetate; TPA) and calcium ionophore (A23187)-mediate...

We investigated the mechanisms by which caffeic acid phenethyl ester (CAPE), a phenolic antioxidant, inhibited the stimulation of prostaglandin (PG) synthesis in cultured human oral epithelial cells and in an animal model of acute inflammation. Treatment of cells with CAPE (2.5 mg/ml) suppressed phorbol ester (12-O-tetradecanoylphorbol-13-acetate; TPA) and calcium ionophore (A23187)-mediated in...

Examination of the helminth communities in 25 yellow-billed ducks (Anas undulata), 21 red-billed ducks (Anas erythrorhyncha), ten Cape teal (Anas capensis) and seven Cape shovellers (Anas smithii) that had overwintered at Barberspan, revealed differences in community structure. Infracommunities in yellow-billed and red-billed ducks were characterized by low diversity and high eveness, and gener...

1​ Gene Expression & Biophysics Group, CSIR Synthetic Biology ERA, Pretoria, 0001, South Africa. 2​ Institute of Infectious Diseases & Molecular Medicine (IDM), Division of Chemical Systems & Synthetic Biology, University of Cape Town, Cape Town, 7925, South Africa. 3​ KwaZulu-Natal Research Institute for TB-HIV (K-RITH), Durban, 4001, South Africa. 4​ University of KwaZulu-Natal, Durban, 404...

D. A. Auger, X. zhong, E. Meintjes, F. Epstein, and B. Spottiswoode MRC/UCT Medical Imaging Research Unit, University of Cape Town, Cape Town, Western Cape, South Africa, MR R&D Collaborations, Siemens Medical Solutions, Atlanta, GA, United States, 3Departments of Radiology and Biomedical Engineering, University of Virginia, Charlottesville VA, United States, Radiology, University of Stellenbos...

1t d reid, 2H Ipp, 3L Becker, 1R H Glashoff. 1Division of Medical Virology, Department of Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa; 2Division of Haematology, Department of Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University & NHLS, Cape Town, South Africa; 3Desmond Tutu Foundation for HIV Research, University of...

Caffeic acid phenethyl ester (CAPE), an active component extracted from honeybee hives, exhibits anti-inflammatory and anticancer activities. However, the molecular mechanism by which CAPE affects oral cancer cell metastasis has yet to be elucidated. In this study, we investigated the potential mechanisms underlying the effects of CAPE on the invasive ability of SCC-9 oral cancer cells. Results...