A complex network of interactions between the stroma, the extracellular matrix and the epithelium drives mammary gland development and function. Two main assumptions in chemical carcinogenesis of the mammary gland have been that carcinogens induce neoplasia by causing mutations in the DNA of the epithelial cells and that the alterations of tissue architecture observed in neoplasms are a consequ...

The carcinogen 4,4'-diaminobiphenyl (benzidine) has been compared in vitro with its terphenyl analogue 4,4''-diaminoterphenyl using the Salmonella reverse mutation assay and the BHK cell-transformation assay. The responses observed, taken together with a consideration of chemical structures, indicate that the terphenyl compound is a potential carcinogen. These findings may contribute to an unde...

In the course of their work on the carcinogenic action of oils and tars on mouse's skin, Twort and Twort (4,5) observed that addition of anhydrous lanolin often led to a reduction in neoplastic response. The inhibitory effect was greater than that obtained with benzene as diluent, and also occurred when lanolin was applied separately to the skin during the intervals between paintings. In view o...

The article examines the harm caused by benzapyrene to environment and human health. Being a carcinogen, accumulating in body, it has mutagenic, embryotoxic, hematotoxin effect. Regulations require removal of contaminated soil from construction site with subsequent disposal. disinfection methods are analyzed.

Helicobacter pylori is an important pathogen to detect and eradicate, particularly as it a known carcinogen. With rising antibiotic resistance control has become challenging. Here the authors propose new algorithm for primary care discuss managing treatment failure.