BACKGROUND AND OBJECTIVE: Hearing loss caused by congenital cytomegalovirus (cCMV) infection was first observed in 1964. Today cCMV is the most common cause of nonhereditary sensorineural hearing loss in childhood. Our objective was to provide an overview of the prevalence of cCMV-related hearing loss, to better define the nature of cCMV-associated hearing loss, and to investigate the importanc...

Importance Congenital cytomegalovirus (cCMV) infection is a major cause of childhood deafness. Most cCMV infections are not diagnosed without newborn screening, resulting in missed opportunities for directed care. Objective To estimate the cost-effectiveness of universal and targeted newborn cCMV screening programs compared with no cCMV screening. Design, Setting, and Participants Models we...

We provide a new characterization of mean-variance hedging strategies in a general semimartingale market. The key point is the introduction of a new probability measure P ⋆ which turns the dynamic asset allocation problem into a myopic one. The minimal martingale measure relative to P ⋆ coincides with the variance-optimal martin-gale measure relative to the original probability measure P .

Abstract Human cytomegalovirus (CMV) causes severe disease in immunocompromised individuals. CMV-based vectors are promising candidates vaccination and immunotherapy approaches. Here, we report on our approach to make chimpanzee CMV (CCMV) available for research vector development. We cloned the CCMV genome created a global picture of infection program by multi-omics. Via engineering distinct r...

We present a threshold-based cardinality inimization formulation for the security-constrained economic dispatch problem. The model aims to minimize operating cost of system while simultaneously reducing number lines in emergency zones during contingency events. allows operator monitor duration which operate and ensure that they are within acceptable reliability standards determined by operators...

Structural transitions in viral capsids play a critical role in the virus life cycle, including assembly, disassembly, and release of the packaged nucleic acid. Cowpea chlorotic mottle virus (CCMV) undergoes a well-studied reversible structural expansion in vitro in which the capsid expands by 10%. The swollen form of the particle can be completely disassembled by increasing the salt concentrat...

Sparse PCA seeks approximate sparse “eigenvectors” whose projections capture the maximal variance of data. As a cardinality-constrained and non-convex optimization problem, it is NP-hard and is encountered in a wide range of applied fields, from bio-informatics to finance. Recent progress has focused mainly on continuous approximation and convex relaxation of the hard cardinality constraint. In...

Abstract A reformulation of cardinality-constrained optimization problems into continuous nonlinear with an orthogonality-type constraint has gained some popularity during the last few years. Due to special structure constraints, violates many standard assumptions and therefore is often solved using specialized algorithms. In contrast this, we investigate viability a safeguarded multiplier pena...