Familial Hypercholesterolemia To the Editor: Verhaar and colleagues, in their recent article,1 report on improvement in forearm endothelial function after 4 weeks’ oral treatment with folic acid at a dose of 5 mg daily in 20 subjects. They used a randomized crossover design without an intervening washout period. Our research group conducted a similar randomized crossover study of folate supplem...

There is a pressing need to increase the throughput of NMR analysis in fields such as metabolomics and drug discovery. Direct injection (DI) NMR automation is recognized to have the potential to meet this need due to its suitability for integration with the 96-well plate format. However, DI NMR has not been widely used as a result of some insurmountable technical problems; namely: carryover con...

CLINICALCHEMISTRY, Vol.32, No. 7, 1986 1411 using samples of a quality-control product (Monitrol, Dade). Lanolin, mineral oil, petrolatum, and the hand lotion withoutglycerin did not affect the results. Glycerin and all hand lotions containing glycerin falsely increased them by 60 to 3900 mgfL. We have been informed that KOdak plans to supply sample tips in a packaging that precludes their hand...

Physiological mechanisms mediating carryover effects, wherein events or activities occurring in one season, habitat, or life-history stage affect important processes in subsequent life-history stages, are largely unknown. The mechanism most commonly invoked to explain carryover effects from migration centres on the acquisition and utilization of resources (e.g. body mass, or individual 'conditi...

Wepropose a utility-theoretic brand-choice model that accounts for four different sources of state dependence: 1. effects of lagged choices (structural state dependence), 2. effects of serially correlated error terms in the random utility function (habit persistence type 1), 3. effects of serial correlations between utility-maximizing alternatives on successive purchase occasions of a household...