INTRODUCTION Fracture repair constitutes the sequence of cell biological events following bone injury and recapitulates the steps of endochondral ossification observed during embryonic skeletal development and growth. Because of the different phases of fracture healing (inflammation, cartilage formation and remodeling) the fracture callus provides an excellent tool for analysis of cartilage and...

Traumatic injury to articular cartilage can lead to post-traumatic arthritis. We used a custom pendulum device to deliver a single, near-fracture impact to the medial femoral condyles of rabbits. Impact was localized to a region ∼3 mm in diameter, and impact stress averaged ∼100 MPa. Animals were euthanized at 0, 1, and 6 months after impact. Cartilage mechanical properties from impacted and sh...

NEGULESCO, JOHN A. AND JOHN A. EGLITIS. Effect of hypophysectomy and estrogen treatment on long bone fracture healing of young domestic fowls. Ohio J. Sci. 75(5): 217, 1975. Estrogen treatment stimulates osteoblast proliferation at fracture sites of nonhypophysectomized 2-week-old birds. The hormone antagonizes growth factor of the intact 4-week bird, and induces modulation of subperiosteal ost...

It is a routine protocol to examine the soft tissues, cartilage and bone tissues of neck during post-mortem examinations performed in cases hanging-related deaths. Fractures hyoid thyroid cartilage, as well bleeding ecchymoses around first fracture are practically great importance establishing case live hanging. The styloid process thin at base skull that extends downward, medially, anteriorly ...

We proposed a multipronged approach to the management of Freiberg disease. A combined dorsal closing wedge with shortening of the metatarsal and joint debridement and microfracture for treating the Freiberg infarction was done. The hypothesis is that dorsal closing wedge and shortening alone cannot help cartilage regeneration. Addition of micro-fracture aids in cartilage regeneration and debrid...

We proposed a multipronged approach to the management of Freiberg disease. A combined dorsal closing wedge with shortening of the metatarsal and joint debridement and microfracture for treating the Freiberg infarction was done. The hypothesis is that dorsal closing wedge and shortening alone cannot help cartilage regeneration. Addition of micro-fracture aids in cartilage regeneration and debrid...

BACKGROUND Open acetabular fractures in children are rare, but potentially devastating injuries. Secondary to the low incidence, there is an apparent lack of reports on appropriate management strategies for open pediatric acetabular fractures in the literature. METHODS Description of a case study. RESULTS A 3 years and ten months-old girl was ejected as a passenger from an all terrain vehic...

Lead exposure continues to be a significant public health problem. In addition to acute toxicity, Pb has an extremely long half-life in bone. Individuals with past exposure develop increased blood Pb levels during periods of high bone turnover or resorption. Pb is known to affect osteoblasts, osteoclasts, and chondrocytes and has been associated with osteoporosis. However, its effects on skelet...

Results of both clinical and animal studies show that meniscectomy often leads to osteoarthritic degenerative changes in articular cartilage. It is generally assumed that this process of cartilage degeneration is due to changes in mechanical loading after meniscectomy. It is, however, not known why and where this cartilage degeneration starts. Load induced cartilage damage is characterized as e...