BACKGROUND Articular cartilage has poor intrinsic capacity for regeneration because of its avascularity and very slow cellular turnover. Defects deriving from trauma or joint disease tend to be repaired with fibrocartilage rather than hyaline cartilage. Consequent degenerative processes are related to the width and depth of the defect. Since mesenchymal stem cells (MSCs) deriving from patients ...

BACKGROUND Cartilage tissue has limited regenerative capacity and the management of cartilage defects has always been a challenging issue. Platelet-rich plasma (PRP) has been recently been used to improve healing of cartilage defects. In the present experiment, we aimed to investigate the effects of PRP on regeneration capacity as well as survival of the cartilage grafts in a rabbit model. ME...

To repair complexly shaped tissue defects, an injectable cell carrier is desirable to achieve an accurate fit and to minimize surgical intervention. However, the injectable carriers available at present have limitations, and are not used clinically for cartilage regeneration. Here, we report nanofibrous hollow microspheres self-assembled from star-shaped biodegradable polymers as an injectable ...

Introduction The regeneration of articular cartilage remains a challenge and is an unmet clinical need in orthopaedic surgery. Since hyaline articular cartilage will not heal spontaneously, these lesions eventually lead to degenerative joint disease. Cartilage abrasion, subchondral drilling, and microfracture techniques stimulate articular cartilage healing by introducing endogenous “stem cells...

Biomechanics plays a pivotal role in articular cartilage development, pathophysiology, and regeneration. During embryogenesis and cartilage maturation, mechanical stimuli promote chondrogenesis and limb formation. Mechanical loading, which has been characterized using computer modeling and in vivo studies, is crucial for maintaining the phenotype of cartilage. However, excessive or insufficient...

Advanced cell-based therapies are promising approaches for stimulating full regeneration of cartilage lesions. In addition to a few commercially available medicinal products, several clinical and preclinical studies are ongoing worldwide. In preclinical settings, high-quality cartilage tissue has been produced using combination strategies involving stem or progenitor cells, biomaterials, and bi...

Tail regeneration in urodeles requires the coordinated growth and patterning of the regenerating tissues types, including the spinal cord, cartilage and muscle. The dorsoventral (DV) orientation of the spinal cord at the amputation plane determines the DV patterning of the regenerating spinal cord as well as the patterning of surrounding tissues such as cartilage. We investigated this phenomeno...

INTRODUCTION: While allogeneic transplantation has attracted much attention in regenerative medicine, animal models approximating safety and efficacy are continued to be explored in translational research because cell sources and transplantation modalities are diverse. Currently, we are preparing for a clinical study using allogeneic chondrocyte sheets for articular cartilage regeneration. In t...

Osteoarthritis (OA) is a rheumatic disease leading to chronic pain and disability with no effective treatment available. Recently, allogeneic human mesenchymal stromal/stem cells (MSC) entered clinical trials as a novel therapy for OA. Increasing evidence suggests that therapeutic efficacy of MSC depends on paracrine signalling. Here we investigated the role of extracellular vesicles (EVs) secr...

We proposed a multipronged approach to the management of Freiberg disease. A combined dorsal closing wedge with shortening of the metatarsal and joint debridement and microfracture for treating the Freiberg infarction was done. The hypothesis is that dorsal closing wedge and shortening alone cannot help cartilage regeneration. Addition of micro-fracture aids in cartilage regeneration and debrid...