TRPM7 is a potential therapeutic target for treatment of prostate cancer. In this study, we investigated the effects of nonselective TRPM7 inhibitor carvacrol on cell proliferation, migration, and invasion of prostate cancer PC-3 and DU145 cells. Our results showed that carvacrol blocked TRPM7-like currents in PC-3 and DU145 cells and reduced their proliferation, migration, and invasion. Moreov...

AIM The biopotential of the essential oils of the Greek aromatic plants Satureja thymbra and Satureja parnassica were investigated, together with their major components carvacrol, thymol, γ-terpinene and p-cymene. MATERIALS AND METHODS Antioxidant and cancer cell cytotoxic properties were determined using 2,2-diphenyl-1-picrylhydrazyl and sulforhodamine B assays, respectively. The antiprolife...

Objective The preventive effect of Zataria multiflora in animal models of asthma has been reported. In the present study, its effect on wheezing, forced expiratory volume in 1 second, and plasma nitrite (NO2-) in asthmatic patients was studied. Materials and Methods In this study, forty asthmatic patients including 15 males and 25 females (aged 45.8±6.21 years) were randomly allocated in four...

This work covers the chemical composition and antimicrobial activities of the essential oils isolated from Satureja thymbra and Thymbra spicata analyzed using gC/MS. The main components of S. thymbra oil were thymol (33.8 %), γ-terpinene (30.8 %) and p-cymene (11.8 %). The main components in T. spicata oil were carvacrol (74.5 %) and γ-terpinene (11.2 %). The oils and their main components, thy...

The question addressed was whether the essential oil components, carvacrol and cinnamaldehyde, would have an interactive effect with regard to growth performance. One-day old female broiler chickens were subjected to one of 5 dietary treatments for 21 days: a base diet as a negative control, the base diet with 1% Carboxymethyl cellulose (CMC), the CMC diet with 200 ppm carvacrol, the CMC diet w...

Tolerogenic dendritic cells (DCs) can induce regulatory T cells and dampen pathogenic T cell responses. Therefore, they are possible therapeutic targets in autoimmune diseases. In this study we investigated whether mouse tolerogenic DCs are induced by the phytonutrient carvacrol, a molecule with known anti-inflammatory properties, in combination with a physiological stress. We show that treatme...

AIMS To investigate the antiviral efficacy of oregano oil and its primary active component, carvacrol, against the nonenveloped murine norovirus (MNV), a human norovirus surrogate. METHODS AND RESULTS Along with an observed loss in cell culture infectivity, the antiviral mechanisms of action were determined in side-by-side experiments including a cell-binding assay, an RNase I protection assa...

OBJECTIVE Pharmacological effects of carvacrol such as its anti-inflammatory activities have been shows. In this study the effects of carvacrol on serum levels of total protein (TP), phospholipase A2 (PLA2) and histamine in sensitized guinea pigs was evaluated. MATERIALS AND METHODS Sensitized guinea pigs were given drinking water alone (group S), drinking water containing three concentration...

The aim of this study was to identify the composition of the essential oil from leaves of Lippia sidoides (EOLS), a typical shrub commonly found in the dry northeast of Brazil, popularly known as "alecrim-pimenta". Additionally, we investigated the nymphicidal, ovicidal, phagoinhibitory and excretion effects of EOLS, its major constituent thymol and its isomer carvacrol, on fourth instar nymphs...

Hydrodistilled volatile oils, as well as the extracts from waste water after hydrodistillation from the aerial parts of Satureja montana and Satureja cuneifolia, growing wild at Mt. Biokovo (Croatia), were analyzed by GC-MS. Sixty compounds were identified in four samples. The major constituents of essential oil obtained from the plant material of S. montana were carvacrol (63.4%) and thymol (1...