Tuberous Sclerosis Complex (TSC) is a genetic disease causing uncontrolled growth of hamartomas involving different organ systems. In the last decade, dysregulation of the mTORC1 pathway was shown to be a main driver of tumor growth in TSC. Recently, a new crosstalk was detected between the mTORC1 and the Hippo-YAP pathway, another major cell signaling cascade controlling cell growth and organ ...

Fast and accurate transient response is the main requirement in electric machine position control. Conventional cascade control structure has sluggish response due to the limitation of inner control loop bandwidth. In this paper, in order to decrease the Permanent Magnet Synchronous Motor (PMSM) transient response time it can be used reference model using feed-forward signals. In this structure...

The ball and beam system is one of the most popular laboratory setups for control education. In this paper, we design a fuzzy PD cascade controller for a ball and beam system using Asexual Reproduction Optimization (ARO) technique. The ball & beam system consists of a servo motor, a grooved beam, and a rolling ball. This system utilizes a servo motor to control ball’s position on the beam. Chan...

In this paper, the problems of control and stabilization of switched nonlinear cascade systems is investigated. The so called simultaneous domination limitation (SDL) is introduced in previous works to assure the existence of a common quadratic Lyapunov function (CQLF) for switched nonlinear cascade systems. According to this idea, if all subsystems of a switched system satisfy the SDL, a CQLF ...

during the last years the total cost of lng technology has decreased significantly due to improvements of the liquefaction process. however, many liquefaction plants that are still in operation use a three-cascade refrigeration system. in this paper, an advanced exergetic analysis is applied to better understand the operation of a three-cascade refrigeration system for liquefaction of natural g...

proton exchange membrane fuel cells (pemfcs) with a dead-ended anode and cathode can obtain high hydrogen and oxygen utilization by a comparatively simple system. nevertheless, the accumulation of the water in the anode and cathode channels might cause a local fuel starvation degrading the performance and durability of pemfcs. in this study, a brand new design for a polymer electrolyte membrane...

A cascade of two-pole-two-zero filter stages is a good model of the auditory periphery in two distinct ways. First, in the form of the pole-zero filter cascade, it acts as an auditory filter model that provides an excellent fit to data on human detection of tones in masking noise, with fewer fitting parameters than previously reported filter models such as the roex and gammachirp models. Second...

Multiple core-sheath flowwas realized usingmatrix arrangement of 3D sheath flows.The sheath flowwas hydrodynamically formed in a flow shift area which has symmetrical microgrooves on channel walls. Vertical and horizontal alignments of the sample streams are a key element of matrix configuration. The flow shift areas were connected in parallel to achieve horizontal alignment of the sheath flow....

In this paper, a very recent chaos control method that stabilizes chaotic systems by introducing small perturbations in the system variables [l] and a new synchronization method that reproduces the driving signal with a single connection [2] are simultaneously applied t o small networks of chaotic electronic circuits ( the Chua circuits [3]) . \ire stabilize a Chua circuit (which acts as drive ...

The corpus callosum is the most prominent commissural connection between the cortical hemispheres, and numerous neurodevelopmental disorders are associated with callosal agenesis. By using mice either with meningeal overgrowth or selective loss of meninges, we have identified a cascade of morphogenic signals initiated by the meninges that regulates corpus callosum development. The meninges prod...