In the article “Bipartite Interaction between Neurofibromatosis Type I Protein (Neurofibromin) and Syndecan Transmembrane Heparan Sulfate Proteoglycans” by Yi-Ping Hsueh, Anne M. Roberts, Manuela Volta, Morgan Sheng, and Roland G. Roberts, which appeared on pages 3764 –3770 of the June 1, 2001 issue, “In B, the same protein samples were used to analyze the subcellular fractionation of neurofibr...

J. Takanashi H. Arai S. Nabatame S. Hirai S. Hayashi J. Inazawa N. Okamoto A.J. Barkovich SUMMARY: Mutations of the CASK gene are associated with X-linked mental retardation with microcephaly and disproportionate brain stem and cerebellar hypoplasia in females. The areas of the cerebrum, corpus callosum, pons, midbrain, and cerebellar vermis and hemisphere and a ratio of cerebrum/ corpus callos...

Polarized expression of the Kir 2.3 channel in renal epithelial cells is influenced by the opposing activities of two different PDZ proteins. Mammalian Lin-7 (mLin-7) directly interacts with Kir 2.3 to coordinate basolateral membrane expression, whereas the tax interacting protein 1 (TIP-1), composed of a single PDZ domain, competes for interaction with mLin-7 and drives Kir 2.3 into the endocy...

Hisse senedi fiyatının belirlenmesinde, arz-talep etkisiyle birlikte, ülkenin ekonomik durumu, gelecek beklentileri ve işletmelerin performansı gibi faktörler oldukça etkilidir. Bu kapsamda, havayolu işletmelerine ait operasyonel göstergelerin hisse fiyatı ile ilişkilerinin ortaya konulması hedeflenmektedir. Uygulamada 6 düşük maliyetli havayollarına 2005-2017 yıllarını kapsayan yıllık veriler,...

Tbr-1, a neuron-specific T-box transcription factor, plays a critical role in brain development. Here, we performed a computational search using the non-palindromic T-box binding sequence, namely the non-palindromic T-element, to determine the putative downstream target genes of Tbr-1. More than 20 identified genes containing the non-palindromic T-element in the 5' regulatory region were found ...

We have reconstituted a eukaryotic leading/lagging strand replisome comprising 31 distinct polypeptides. This study identifies a process unprecedented in bacterial replisomes. While bacteria and phage simply recruit polymerases to the fork, we find that suppression mechanisms are used to position the distinct eukaryotic polymerases on their respective strands. Hence, Pol ε is active with CMG on...

Vertebrate CASK is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. CASK is present in the nervous system where it binds to neurexin, a transmembrane protein localized in the presynaptic membrane. The Drosophila homologue of CASK is CAKI or CAMGUK. CAKI is expressed in the nervous system of larvae and adult flies. In adult flies, the expression of caki is particu...

Preliminary studies of used fuel generated in the US Department of Energy’s Advanced Fuel Cycle Initiative have indicated that current used fuel transport casks may be insufficient for the transportation of said fuel. This work considers transport of three 5-year-cooled oxide Advanced Burner Reactor used fuel assemblies with a burn-up of 160 MWD/kg. A transport cask designed to carry these asse...

Increasing evidence indicates the importance of extracellular adenosine triphosphate (ATP) in the modulation of neuronal function. In particular, fine control of ATP release and the selective and discrete ATP receptor operation are crucial elements of the crosstalk between neuronal and non-neuronal cells in the peripheral and central nervous systems. In peripheral neurons, ATP signaling gives a...

Hearing in mammals depends upon the proper development of actin-filled stereocilia at the hair cell surface in the inner ear. Whirlin, a PDZ domain-containing protein, is expressed at stereocilia tips and, by virtue of mutations in the whirlin gene, is known to play a key role in stereocilia development. We show that whirlin interacts with the membrane-associated guanylate kinase (MAGUK) protei...