The aim of this study was to investigate the activity apoptosis and autophagy in animals (cows, horses, donkeys, dogs cats) naturally infected with rabies by using immunohistochemistry, immunofluorescence, qPCR. mRNA transcript levels caspase-3, Bax, Bcl2 LC3B were determined Caspase-3 AIF immunopositivity not observed immunohistochemical immunofluorescence staining, whereas intensively compare...

The prognostic value of proliferation index (PI) and apoptotic index (AI), caspase-8, -9 and -10 expression have been investigated in primary Ewing's sarcoma family of tumours (ESFT). Proliferating cells, detected by immunohistochemistry for Ki-67, were identified in 91% (91/100) of tumours with a median PI of 14 (range 0-87). Apoptotic cells, identified using the TUNEL assay, were detected in ...

objective(s):several investigations have revealed that caspase-14 is responsible for the epidermal differentiation and cornification, as well as the regulation of moisturizing effect. however, the precise regulation mechanism is still not clear. this study was aimed to investigate the expression of caspase-14 in filaggrin-deficient normal human epidermal keratinocytes (nheks) and to explore the...

Cancer-associated fibroblasts (CAF) are highly prevalent cells in the tumor microenvironment clear cell renal carcinoma (ccRCC). CAFs exhibit a pro-tumor effect vitro and have been implicated proliferation, metastasis, treatment resistance. Our objective is to analyze geospatial distribution of with proliferating apoptotic ccRCC determine associations survival systemic treatment. Pre-treatment ...

salvia chorassanica bunge is one of the iranian endemic species of salvia. there is not any reported literature on s. chorassanica. this study was designed to examine the in-vitro anti-proliferative and proapoptotic effects of the methanol extract of s. chorassanica and its fractions on hela cell line. cells were cultured in ex-cell®, an animal free medium specially designed for hela cell line ...

caspase-3, one of the dominant effectors caspases, is activated in almost every model of apoptosis with various signaling pathways. hence, inhibition of caspase-3 has become an attractive target in the treatment of neurodegenerative diseases. caspase-3 inhibitory activities of some 1,2-benzisothiazol-3-one derivatives were modeled by quantitative structure–activity relationship (qsar) using ste...

mono-targeting by imatinib as a main antitumor agent does not always accomplish complete cancer suppression. 2,5-dimethyl-celecoxib (dmc) is a close structural analog of the selective cyclooxygenase-2 (cox-2) inhibitor, celecoxib, that lacks cox-2 inhibitory function. in this study, we aimed to show the apoptotic effects of imatinib in combination with dmc in human ht-29 colorectal cancer (crc)...

Objective(s):Several investigations have revealed that caspase-14 is responsible for the epidermal differentiation and cornification, as well as the regulation of moisturizing effect. However, the precise regulation mechanism is still not clear. This study was aimed to investigate the expression of caspase-14 in filaggrin-deficient normal human epidermal keratinocytes (NHEKs) and to explore the...