Calpain, an intracellular Ca²⁺-dependent cysteine protease, is known to play a role in a wide range of metabolic pathways through limited proteolysis of its substrates. However, only a limited number of these substrates are currently known, with the exact mechanism of substrate recognition and cleavage by calpain still largely unknown. While previous research has successfully applied standard m...

Atherosclerosis, Obesity, and Bone Traits To the Editor: I write regarding publications by Mehrabian et al1,2 appearing in Circulation Research and a subsequent publication by Kuhn et al3 appearing in Arteriosclerosis, Thrombosis, and Vascular Biology. The key implication from the combination of these reports was that amino acid substitutions in arachidonate 5-lipoxygenase (ALOX5) could account...

Multi-context team decision making under time stress is an extremely challenging issue faced by various real world application domains. In this study we employ an experience-based cognitive agent architecture (R-CAST) to address the informational challenges associated with military command and control (C) decision making teams, the performance of which can be significantly affected by dynamic c...

This document contains several sections of the CAST-256 AES Submission Package delivered to NIST on June 9, 1998. All complete submissions received by NIST will be made public in late August at the First AES Candidate Conference, but the following material is being made available now so that public analysis of the CAST-256 algorithm may begin (see, for example, http://www.ii.uib.no/~larsr/aes.h...

The objectives of this project are; to demonstrate that hydrographic variability in shelf waters can be hind-cast, to a quantifiable degree, using a simple 1 dimensional physical model. To demonstrate that the model can be used to interpret the regional variability of ocean colour in terms of the mechanisms of physical forcing on phytoplankton growth. The effects of tidal front dynamics and the...

Strain CAST/Ei (CAST) mice exhibit unusually low levels of high density lipoproteins (HDL) as compared with most other strains of mice, including C57BL/6J (B6). This appears to be due in part to a functional deficiency of lecithin:cholesterol acyltransferase (LCAT). LCAT mRNA expression in CAST mice is normal, but the mice exhibit several characteristics consistent with functional deficiency. F...

BACKGROUND/AIMS The genetic basis for ingestive behaviors is virtually unknown. Quantitative trait loci (QTLs) for carbohydrate and energy intake map to mouse chromosome 17 and were previously confirmed by a congenic strain bearing CAST/Ei (CAST) donor segment on the C57BL/6J (B6) background. METHODS We used microarray technology to facilitate gene identification. Gene expression was compared...

The genetic diversity of modern populations domestic animals is very important for improving breeds, their adaptation to various environmental conditions, as well obtaining high-quality livestock products, in particular meat. calpastatin gene (CAST) considered one the promising markers growth intensity and meat quality. article presents an analysis literature review on CAST sheep from following...

BACKGROUND The damaging effects of exposure to environmental toxicants differentially affect genetically distinct individuals, but the mechanisms contributing to these differences are poorly understood. Genetic variation affects the establishment of the gene regulatory landscape and thus gene expression, and we hypothesized that this contributes to the observed heterogeneity in individual respo...