Although invasive and metastatic progression via the epithelial-mesenchymal transition (EMT) and acquisition of resistance to castration are both critical steps in prostate cancer, the molecular mechanism of this interaction remains unclear. In this study, we aimed to elucidate the interaction of signaling between castration resistance and EMT, and to apply this information to the development o...

Castration induces the accumulation of body fat and deposition of intramuscular fat in Korean cattle, resulting in improved beef quality. However, little is known about the metabolic adaptations in the liver following castration. To understand changes in lipid metabolism following castration, hepatic expression levels of lipid metabolism genes were compared between Korean bulls and steers. Stee...

The treatment of patients with prostate cancer, who do not qualify for the radical therapy is based on use surgical or pharmacological castration methods. effectiveness so-called androgen deprivation tends to decrease over time. Even in absence distant metastases imaging studies, resistance hormonal may be developed. At this moment, new generation receptor inhibitors reduce risk death. paper pr...

The objectives of this study were to determine i) the effect of castration, dehorning, or both on the physiology and behavior of 3-mo-old Holstein calves, and ii) the effectiveness of pain relief to alleviate the pain caused by castration and/or dehorning. Holstein calves (n = 80) were assigned randomly to 1 of 8 treatments (10 calves/treatment): i) control handling (SHAM); ii) surgical castrat...

Insulin-like growth factor (IGF)-I has well-characterized mitogenic and antiapoptotic effects that are essential for maintenance of the normal prostate and may be important during regression of the normal prostate and/or prostate tumors induced by androgen-targeting therapies for prostate cancer. IGF-I activity is modulated by IGF-binding proteins (IGFBPs). Here we examine IGFBP expression duri...

Forty-seven Holstein calves (130 +/- 3.43 kg of BW and 95 +/- 1.5 d of age) were randomly assigned to 2 treatments [intact (INT), n = 23; or castrated (CAS), n = 24] to evaluate the effect of ring castration at 3 mo of age on welfare indicators. Castration was performed with local anesthesia (2% lidocaine, 3 mL in each testis and 2 mL in the scrotum) and analgesia (flunixin meglumine, intramusc...

Surgical castration is a common management practice performed on male pigs to prevent the occurrence of boar taint. Surgical castration is known to cause physiological and behavioral changes in pigs indicative of pain-induced distress; however, it is commonly performed without pain relief. The objective of this study was to evaluate the effectiveness of carbon dioxide gas (CO(2)) anesthesia and...

Leiomyomatosis peritonealis disseminata is a very rare condition characterized by the development of multiple smooth muscle-like nodules in the peritoneal cavity. It is associated with increased serum levels of gonadal steroids. The present report describes a 29-year-old patient underwent transabdominal hysterectomy and Bilateral Salpingo oophorectomy six years ago because of leiomyomatosis per...

Castration of male animal's leads to a reduction in aggressive behavior, which animals will avoid wasting energy resulting to economic production of the animal, grows. It also reduces damage and bruising animals and increases normed meat producing at slaughter. In this study, 20 lambs Ghezel breed in four age groups, group 1: one month (n = 4), group 2: two months (n = 4) Group 3: three months ...