AIMS Cystathionine β-synthase (CBS) catalyzes the first and rate-limiting step in the two-step trans-sulfuration pathway that converts homocysteine to cysteine. It is also one of three major enzymes responsible for the biogenesis of H2S, a signaling molecule. We have previously demonstrated that CBS is activated in cells challenged by oxidative stress, but the underlying molecular mechanism of ...

OBJECTIVE To determine the brain areas associated with specific components of ideomotor apraxia (IMA) in corticobasal syndrome (CBS). DESIGN Case-control and cross-sectional study. PARTICIPANTS Forty-eight patients with CBS and 14 control subjects. Intervention Administration of the Test of Oral and Limb Apraxia. MAIN OUTCOME MEASURES Differences between patients with CBS and healthy cont...

Human cystathionine beta-synthase (CBS) catalyzes the first irreversible step in the transsulfuration pathway and commits homocysteine to the synthesis of cysteine. Mutations in CBS are the most common cause of severe hereditary hyperhomocysteinemia. A yeast two-hybrid approach to screen for proteins that interact with CBS had previously identified several components of the sumoylation pathway ...

The Cajal (coiled) body (CB) is a structure enriched in proteins involved in mRNA, rRNA, and snRNA metabolism. CBs have been shown to interact with specific histone and snRNA gene loci. To examine the potential role of CBs in U2 snRNA metabolism, we used a variety of genomic and oligonucleotide probes to visualize in situ newly synthesized U2 snRNA relative to U2 loci and CBs. Results demonstra...

In this work, regular convergence patterns of the structural, harmonic, and VPT2-calculated anharmonic vibrational parameters of ethylene towards the Kohn-Sham complete basis set (KS CBS) limit are demonstrated for the first time. The performance of the VPT2 scheme implemented using density functional theory (DFT-BLYP and DFT-B3LYP) in combination with two Pople basis sets (6-311++G** and 6-311...

Conflict-Based Search (CBS) and its enhancements, Meta-Agent CBS and bypassing conflicts are amongst the strongest newly introduced algorithms for Multi-Agent Path Finding. This paper introduces two new improvements to CBS and incorporates them into a coherent, improved version of CBS, namely ICBS. Experimental results show that each of these improvements further reduces the runtime over the ex...

The success of a Component Based System (CBS) relies on integrating individual components. CBS integration testing encounters challenges similar to traditional testing; and aims to prioritize test cases with a potential benefit of improving the rate of fault detection. In this paper, we present a CBS integration testing framework to identify integration test criteria and prioritize test cases. ...

detection while CBS in the presence of Cu displayed significant fluorescence enhancement. However, the metal ions Ag, Ca, Co, Cr, Fe, Fe, Hg, K, Mg, Mn, Ni, Pb, and Zn produced only minor changes in the fluorescence values of the system. The binding constant (Ka) of Cu 2+ binding to CBS was found to be 7.28 10 M . The binding ratio of CBS–Cu complexes was determined from the Job plot to be 1 : ...

Fifty consecutive patients with non-ulcer dyspepsia and a Campylobacter associated gastritis (CAG) were randomly assigned to treatment with colloidal bismuth subcitrate (CBS) 240 mg twice daily or placebo, according to a double blind study design. After the blind treatment an 'open' treatment with CBS was started in both groups. Twenty six patients treated with CBS showed a significant reductio...

We studied coherent backscattering (CBS) of light from opal photonic crystals with incomplete band gaps. We observed a dramatic broadening of the CBS cone for incident angles close to the Bragg condition in the crystals. We modify the conventional CBS theory to incorporate Bragg attenuation resulting from the photonic band structure. By fitting the CBS data with the modified theory, we extract ...