نتایج جستجو برای: ccl22

تعداد نتایج: 1448  

Journal: :Clinical and vaccine immunology : CVI 2011
Yonghong Feng Hongyun Yin Guangliang Mai Ling Mao Jun Yue Heping Xiao Zhongyi Hu

The serum levels of Th2 markers, including CCL17 (thymus and activation-regulated chemokine [TARC]), CCL22 (macrophage-derived chemokine [MDC]), and soluble CD30, were measured in 101 HIV-negative tuberculosis patients, 103 healthy community controls, and 18 tuberculosis patients in recovery. The levels of CCL17/TARC (249.8 ± 19.91 versus 143.9 ± 10.54, P < 0.0001) and sCD30 (7.78 ± 0.44 versus...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2013
Andrew J Glowacki Sayuri Yoshizawa Siddharth Jhunjhunwala Andreia E Vieira Gustavo P Garlet Charles Sfeir Steven R Little

The hallmark of periodontal disease is the progressive destruction of gingival soft tissue and alveolar bone, which is initiated by inflammation in response to an invasive and persistent bacterial insult. In recent years, it has become apparent that this tissue destruction is associated with a decrease in local regulatory processes, including a decrease of forkhead box P3-expressing regulatory ...

Journal: :Journal of immunology 2002
Daniele D'Ambrosio Cristina Albanesi Rosmarie Lang Giampiero Girolomoni Francesco Sinigaglia Carlo Laudanna

Chemokines control the specificity of lymphocyte homing. Numerous chemokines have been identified but the significance of redundancy in chemokine networks is unexplained. Here we investigated the biological significance of distinct chemokines binding to the same receptor. Among CCR4 ligands, skin vessels endothelial cells present C-C chemokine ligand (CCL) 17 but not CCL22 consistent with CCL17...

2017
Jeroen K Buskermolen Sanne Roffel Susan Gibbs

The focus of this study was to determine which chemokine receptors are present on oral fibroblasts and whether these receptors influence proliferation, migration, and/or the release of wound healing mediators. This information may provide insight into the superior wound healing characteristics of the oral mucosa. The gingiva fibroblasts expressed 12 different chemokine receptors (CCR3, CCR4, CC...

Journal: :The European respiratory journal 2004
C Pilette J N Francis S J Till S R Durham

T-helper (Th) 2 cytokines are thought to mediate most features of allergic inflammation in atopic asthma. However, it remains unclear whether chemokine pathways direct selective recruitment of Th2 cells to the airways during human allergic responses. Bronchoalveolar lavage (BAL) was performed in 15 nonsmoking mild atopic asthmatics before and 24 h after a fibreoptic segmental allergen challenge...

Journal: :The Journal of Experimental Medicine 2001
Andrea Iellem Margherita Mariani Rosmarie Lang Helios Recalde Paola Panina-Bordignon Francesco Sinigaglia Daniele D'Ambrosio

Chemokines dictate regional trafficking of functionally distinct T cell subsets. In rodents and humans, a unique subset of CD4(+)CD25(+) cytotoxic T lymphocyte antigen (CTLA)-4(+) regulatory T cells (Treg) has been proposed to control peripheral tolerance. However, the molecular basis of immune suppression and the trafficking properties of Treg cells are still unknown. Here, we determined the c...

Journal: :Journal of immunology 2010
Zhi-Jian Ye Qiong Zhou Yong-Yao Gu Shou-Ming Qin Wan-Li Ma Jian-Bao Xin Xiao-Nan Tao Huan-Zhong Shi

IL-17-producing CD4(+) T (Th17) cells have been found to be increased in some human cancers; however, the possible implication of Th17 cells in regulating antitumor responses in malignant pleural effusion (MPE) remains to be elucidated. In the current study, distribution and phenotypic features of Th17 cells in both MPE and peripheral blood from patients with lung cancer were determined by flow...

2017
Manabu Inoue Junko Yamada Emiko Aomatsu-Kikuchi Kazuro Satoh Hisatomo Kondo Akira Ishisaki Naoyuki Chosa

Recently, we identified the scrapie responsive gene 1 (SCRG1) secreted from mesenchymal stem cells (MSCs) and its receptor bone marrow stromal cell antigen 1 (BST1) as positive regulators of stem cell qualities such as self‑renewal, migration abilities, and osteogenic differentiation potential. Here, we examined the effect of the paracrine activity of SCRG1 in macrophages. The mouse macrophage‑...

2017
Kuo-Wei Yeh Chih-Yung Chiu Kuan-Wen Su Ming-Han Tsai Man-Chin Hua Sui-Ling Liao Shen-Hao Lai Li-Chen Chen Tsung-Chieh Yao Jing-Long Huang

Atopic diseases are known to be characterized by a T helper (Th) 2-skewed immunity; however, there are few studies addressing the Th1/Th2 immunity at birth related to the development of atopic diseases in early childhood. We investigated 186 children followed up regularly at the clinic for 4 years in a birth cohort study. The Th1-associated CXC chemokine ligand (CXCL)-10, CXCL11, and the Th2-as...

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