It is unknown why the potencies and efficacies of long-chained guanidine-type histamine H2-receptor (H2R) agonists are lower at the H2R of human neutrophils than at the H2R of the guinea pig atrium. To elucidate these differences, we analyzed fusion proteins of the human H2R (hH2R) and guinea pig H2R (gpH2R), respectively, and the short splice variant of Gsalpha (GsalphaS) expressed in Sf9 cell...

Simple expressions for the bending and the base-stacking energy of double-stranded semiflexible biopolymers (such as DNA and actin) are derived. The distribution of the folding angle between the two strands is obtained by solving a Schrödinger equation variationally. Theoretical results based on this model on the extension versus force and extension versus degree of supercoiling relations of DN...

1Department of Dental Biomaterials, Nihon University School of Dentistry at Matsudo, 2-870-1 Sakaecho Nishi, Chiba, Matsudo 271-8587, Japan 2Department of Oral Biomaterials and Technology, Showa University School of Dentistry, Tokyo 142-8555, Japan 3Department of Dental Materials Science, Faculty of Dentistry, The University of Hong Kong, Sai Ying Pun, Hong Kong 4Department of Clinical Oral Phy...

Delivery of tumor-associated Ag-derived peptides in a high immunogenic form represents one of the key issues for effective peptide-based cancer vaccine development. We report herein the ability of nonpathogenic filamentous bacteriophage fd virions to deliver HLA-A2-restricted MAGE-A10(254-262)- or MAGE-A3(271-279)-derived peptides and to elicit potent specific CTL responses in vitro and in vivo...

Innocent Praecordial Murmurs in Children H. A. Fleming, F.R.C.P ................... 270 Cervical Cone Biopsy and Fertility M. M. Boddington, M.R.C.PATH., and A. I. Spriggs, F.R.C.P ......................... 271 Cervical Injury and Prostaglandins I. L. Craft, M.R.C.O.G., and E. Youssefnejadian, PH.D ............................. 271 Meningococcal Disease R. J. Fallon, F.R.C.PATH.; R. B. McGucken...

BACKGROUND Approximately 5.5 million Americans are living with Alzheimer's disease (AD) in 2017. YouTube is a popular platform for disseminating health information; however, little is known about messages specifically regarding AD that are being communicated through YouTube. OBJECTIVE This study aims to examine video characteristics, content, speaker characteristics, and mobilizing informatio...

Address for correspondence: Sebastian Goreczny, MD, PhD, Department of Cardiology, Polish Mother’s Memorial Hospital, Research Institute, ul. Rzgowska 281/289, 93–338 Łódź, Poland, tel: +48 42 271 21 84, fax: +48 42 271 14 78, e-mail: [email protected] Conflict of interest: none declared Kardiologia Polska Copyright © Polskie Towarzystwo Kardiologiczne 2017 Retrieving a large embolised...

269 Refractory Chronic Urticaria Treated with Omalizumab Martinez Saenz, NP, Ramírez Del Pozo, ME, Lopez Tiro JJ, and Javier Gomez Vera, MD. Alergia e inmunologia clínica, Hospital Regional Lic. Adolfo Lopez Mateos, Distrito Federal, Mexico. Background: Chronic urticaria (CU) is a common disorder characterized by recurrent episodes of urticaria pruritic erythematous lesions, associated with ang...