نتایج جستجو برای: cd6
تعداد نتایج: 223 فیلتر نتایج به سال:
The appropriate timing of bone marrow transplantation (BMT) for adults with acute myelogenous leukemia (AML) and acute lymphoblastic leukemia (ALL) is controversial. Although allogeneic transplantation results in a lower risk of disease recurrence than intensive chemotherapy alone, overall outcome following BMT may not be improved due to the higher incidence of therapy-related fatal complicatio...
Activated leukocyte cell adhesion molecule (ALCAM) is a that supports T activation, migration, and (lymph)angiogenesis has been shown to contribute the pathology of various immune-mediated disorders, including asthma corneal graft rejection. In contrast monoclonal antibodies (mAbs) targeting ALCAM’s expressed binding partner CD6, no ALCAM-targeting mAbs have thus far entered clinical developmen...
Correction: T cell activation and differentiation is modulated by a CD6 domain 1 antibody Itolizumab
[This corrects the article DOI: 10.1371/journal.pone.0180088.].
The activated leukocyte cell adhesion molecule (ALCAM) mediates dynamic homotypic and heterotypic cellular interactions. Whereas homotypic ALCAM-ALCAM interactions have been implicated in the development and maintenance of tissue architecture and tumor progression, heterotypic ALCAM-CD6 interactions act to initiate and stabilize T-cell-dendritic-cell interactions affecting T-cell activation. Th...
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