نتایج جستجو برای: cd64 in neutrophils

تعداد نتایج: 16979651  

2017
Nandan K. Mondal Shabana Siddique Madhuchanda Banerjee Sanghita Roychoudhury Sayali Mukherjee Mark S. Slaughter Twisha Lahiri Manas R. Ray

BACKGROUND There are a million ragpickers in India who gather and trade recyclable municipal solid wastes materials for a living. The objective of this study was to examine whether their occupation adversely affects their immunity. METHODS Seventy-four women ragpickers (median age, 30 years) and 65 age-matched control housemaids were enrolled. Flow cytometry was used to measure leukocyte subs...

Journal: :Blood 1993
T Valerius R Repp T P de Wit S Berthold E Platzer J R Kalden M Gramatzki J G van de Winkel

Three different classes of Fc receptors for IgG (Fc gamma R) are currently distinguished in humans, of which polymorphonuclear phagocytes (PMN) normally express both low-affinity receptor classes--Fc gamma RII (CD32) and Fc gamma RIII (CD16). During therapy with granulocyte colony-stimulating factor (G-CSF), neutrophils from patients with various malignancies and different hematologic disorders...

Journal: :Molecular cancer therapeutics 2008
Bettina Stahnke Theo Thepen Michael Stöcker Reinhard Rosinke Edgar Jost Rainer Fischer Mehmet K Tur Stefan Barth

Acute myeloid leukemia (AML) cells of subtypes M4 and M5 show enhanced expression of CD64 (FcgammaRI), the high-affinity receptor for IgG, which is normally expressed at high levels only on activated cells of the myeloid lineage. CD64 is therefore a prime target for the specific delivery of cytotoxic agents. A promising toxin candidate is granzyme B, a human serine protease originating from cyt...

Journal: :Cancer research 2003
Mehmet K Tur Michael Huhn Theo Thepen Michael Stöcker Regina Krohn Simon Vogel Edgar Jost Rainhardt Osieka Jan G van de Winkel Rainer Fischer Ricarda Finnern Stefan Barth

CD64, the high affinity receptor for IgG (FcgammaRI) is expressed on acute myeloid leukemia blast cells and has recently been described as a specific target for immunotherapy. To generate a recombinant immunotoxin, the anti-CD64 single chain fragment (scFv) m22 was cloned into the bacterial expression vector pBM1.1 and fused to a deletion mutant of Pseudomonas exotoxin A (ETA'). Genetically mod...

2017
Seok-Beom Yong Hyung Jin Kim Jang Kyoung Kim Jee Young Chung Yong-Hee Kim

A subset of phagocytes including inflammatory monocytes in blood migrate and give rise to macrophages in inflammatory tissues which generated the idea that blood monocytes are the therapeutic targets for drug delivery. Fc gamma receptor I (CD64) is a membrane receptor for the Fc region of immunoglobulin G, primarily expressed on monocyte-lineage, and H22 a monoclonal antibody for human CD64 had...

2016
Radoslav Mladenov Dmitrij Hristodorov Christian Cremer Gerrit Gresch Elena Grieger Lea Schenke Diana Klose Manal Amoury Mira Woitok Edgar Jost Tim H. Brümmendorf Rolf Fendel Rainer Fischer Christoph Stein Theo Thepen Stefan Barth

Fc gamma receptor I (FcγRI, CD64) is a well-known target antigen for passive immunotherapy against acute myeloid leukemia and chronic myelomonocytic leukemia. We recently reported the preclinical immunotherapeutic potential of microtubule associated protein tau (MAP) against a variety of cancer types including breast carcinoma and Hodgkin's lymphoma. Here we demonstrate that the CD64-directed h...

Journal: :Infekciâ i Immunitet 2021

A search for new targeted therapeutic strategies based on examining immunopathogenetic mechanisms emerging co-infections is relevant and may further contribute not only to optimizing choice of immunotropic drugs, but also achieving positive clinical immunological remission abnormal infectious processes. Previously, our studies found that recurrent viral-bacterial respiratory infections are asso...

Journal: :Archives of pathology & laboratory medicine 2007
Cherie H Dunphy Wohzan Tang

CONTEXT Flow cytometric immunophenotyping is a useful ancillary tool in the diagnosis and subclassification of acute myeloid leukemias (AMLs). A recent study concluded that CD64 is sensitive and specific for distinguishing AMLs with a monocytic component (ie, AML M4 and AML M5) from other AML subtypes. However, in that study, the intensity of CD64 was not well defined and the number of non-M4/n...

2014
Meredith J. Crane Jean M. Daley Olivier van Houtte Samielle K. Brancato William L. Henry Jorge E. Albina

The origin of wound repair macrophages is incompletely defined and was examined here in sterile wounds using the subcutaneous polyvinyl alcohol sponge implantation model in mice. Phenotypic analysis identified F4/80(+)Ly6C(hi)CD64(+)MerTK(-) monocytes and F4/80(+)Ly6C(low)CD64(+)MerTK(+) macrophages in the wound. Circulating monocytes were the precursors of inflammatory Ly6C(hi) wound monocytes...

2013
Narutaka Katoh Jinju Nishino Keita Nishimura Chisato Kawabata Yuuko Hotta Toshihiro Matsui Shigeru Nakamura Takashi Matsushita

BACKGROUND Neutrophil CD64 has been reported to be a sensitive and specific infection marker. Its measurement is thus considered to be useful in early diagnosis of post-operative periprosthetic infection. However, even its normal sequential changes after non-infectious total joint arthroplasty have remained ambiguous. Accordingly, we analyzed 2-week sequential neutrophil CD64 expression changes...

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