The promyogenic cell surface molecule Cdo is required for activation of extracellular signal-regulated kinase (ERK) and nuclear factor of activated T cells c3 (NFATc3) induced by netrin-2 in myogenic differentiation. However, the molecular mechanism leading to NFATc3 activation is unknown. Stromal interaction molecule 1 (Stim1), an internal calcium sensor of the endoplasmic reticulum store, pro...

Holoprosencephaly (HPE) is caused by a failure to form the midline of the forebrain and/or midface. It is one of the most common human birth defects, but clinical expression is extremely variable. HPE is associated with mutations in the sonic hedgehog (SHH) pathway. Mice lacking the Shh pathway regulator Cdo (also called Cdon) display HPE with strain-dependent penetrance and expressivity, impli...

In this paper, we review recent advances in pricing tranches of a collateralized debt obligations and credit default swap indexes: one factor Gaussian copula model and its extensions, the structural model, and the loss process model. Then, we propose using heavy-tailed functions in future research. As background, we provide a brief explanation of collateralized debt obligations, credit default ...

Mammalian metabolism of ingested cysteine is conducted principally within the liver. The liver tightly regulates its intracellular cysteine pool to keep levels high enough to meet the many catabolic and anabolic pathways for which cysteine is needed, but low enough to prevent toxicity. One of the enzymes the liver uses to regulate cysteine levels is CDO (cysteine dioxygenase). Catalysing the ir...

n-CdO/p-Si heterojunction diode was fabricated using sol-gel spin coating technique which is a low cost and easily scalable method for preparing of semiconductor films. The structural and morphological properties of CdO film were investigated. The X-ray diffraction (XRD) spectra indicated that the film was of polycrystalline nature. The scanning electron microscopy (SEM) images indicate that th...

Cell-cell interactions between muscle precursors are required for myogenic differentiation; however, underlying mechanisms are largely unknown. Promyogenic cell surface protein Cdo functions as a component of multiprotein complexes containing other cell adhesion molecules, Boc, Neogenin and N-cadherin, and mediates some of signals triggered by cell-cell interactions between muscle precursors. C...

In metazoa and fungi, the catabolic dissimilation of cysteine begins with its sulfoxidation to cysteine sulfinic acid by the enzyme cysteine dioxygenase (CDO). In these organisms, CDO plays an important role in the homeostatic regulation of steady-state cysteine levels and provides important oxidized metabolites of cysteine such as sulfate and taurine. To date, there has been no experimental ev...

Corporate loans tend to be secured, comprising the most senior part of the high-yield capital structure. Trading in loan credit default swap (LCDS) has increased rapidly over the past few years. Only syndicated secured loans of the designated priority (1 Lien, 2 Lien, etc.) are deliverable into the contract and a LCDS contract can be prepaid (cancelled) when no senior secured loan of the design...

High-quality colloidal semiconductor nanocrystals are nanometer-sized, single crystalline fragments of the corresponding bulk crystals, which have well-controlled size and size distribution and are dispersible in desired solvents/media. Recently, semiconductor nanocrystals are of great interest for both fundamental research and technical applications,1-8 due to their strong size dependent prope...