Abstract Background and Aims Acute kidney injury (AKI) is a serious clinical complication that has high morbidity mortality. Although there have been substantial advances in understanding AKI mechanisms, at present, are no effective therapies to treat or prevent it. Method We had formerly found TUG891, GPR120 (a member of the G protein-coupled receptor (GPCR) family) agonist, alleviated tubular...

Cecal diverticulitis is an unusual condition that presents clinically similar to appendicitis. Although it is usually asymptomatic, it may cause inflammation, bleeding, or perforation. The diagnosis is not always easy and in the majority of cases, the diagnosis is usually made at laparotomy. There have been various controversies in the literature regarding the optimal management of cecal divert...

Objective(s): To investigate the protective effect of S-nitrosoglutathione (SNG) pretreatment on acute lung injury (ALI) in septic rats. Materials and Methods: We constructed a rat model of sepsis by cecal ligation and perforation (CLP), and randomly divided into Sham, CLP, and CLP+SNG (0.25 and 0.5 mg/kg) groups. We used H&E; staining an...

Primary small intestinal malignancies are rare and accounting for 1-2% of all gastrointestinal (GIT) tumors. Extranodal lymphomas most commonly found in GIT with majority sites stomach, intestine ileo-cecal junction. Non-Hodgkin’s Lymphoma (NHL) predominantly B cell type constituting 90% cases few T type. The purpose this editorial is to highlight the morphology rarity lymphoma encountered jeju...

Peroxisome proliferator-activated receptor (PPAR)-γ is a ligand-activated transcription factor and regulates inflammation. Posttranslational modifications regulate the function of PPARγ, potentially affecting inflammation. PPARγ contains a mitogen-activated protein kinase (MAPK) site, and phosphorylation by extracellular signal-regulated kinase (ERK)-1/2 leads to inhibition of PPARγ. This study...

Background: In the present study, we hypothesized that conditioned medium (CM) derived from mesenchymal stem cells attenuates the brain oxidative stress in sepsis induced by the cecal ligation and puncture (CLP) model. Methods: This study was performed in the Department of Physiology at Tehran University of Medical Sciences from August 2018 to April 2019. Conditioned medium was collected from ...

PURPOSE To evaluate the effects of copaiba oil administered by different routes on survival of mices subjected to cecal ligation and puncture. METHODS Thirty two mice were distributed into four study groups (N=8): Sham group: normal standard animals; CONTROL GROUP submitted a cecal ligation and puncture (CLP); Gavage group: submitted a CLP, and treat with copaiba oil by gavage; and Subcutan...

Abstract Objective Standard rodent sepsis models as cecal ligation and puncture (CLP) or incision (CLI) are frequently not suited experiments, mainly because they lack surgical repair, difficult to control for severity. The colon ascendens stent peritonitis model (CASP) overcomes some of these limitations. Result Here we present our modification the CASP model, where severity can be controlled ...