Objective(s): The present paper aims to review the studies describing the interactions between HopQ and CEACAMs along with possible mechanisms responsible for pathogenicity of Helicobacter pylori.Materials and Methods: The literature was searched on “PubMed” using different key words including Helicobacter pylori, CEACAM and gastric.<br ...

Zonula occludens proteins (ZO-1, ZO-2, ZO-3), which belong to the family of membrane-associated guanylate kinase (MAGUK) homologs, serve as molecular hubs for the assembly of multi-protein networks at the cytoplasmic surface of intercellular contacts in epithelial and endothelial cells. These multi-PDZ proteins exert crucial functions in the structural organization of intercellular contacts and...

the adhesion molecules are involved in adhesion of leukocytes to endothelial cells and other immune cells. not only adhesion molecules have membrane form, but they also have soluble form. in this paper, we attempted to investigate the concen¬tration of soluble adhesion molecules in the type 1 diabetic patients (n = 40) and healthy subjects (n = 10). the results indicated that there was an incre...

Most common hypotheses of seizure initiation are increased neural excitation, decreased inhibition or both. But, the conditions that lead to these activation states not to be clear yet. Recent studies challenge traditional concepts and indicate new evidence that a key epileptogenic process may actually begin in the blood vessel. Seizures could be initiate by a variety of insults to the brain, s...

Metastasis describes the ability of a tumor to invade normal tissue and generate secondary tumors at sites distant from the primary tumor. The mechanism responsible for the inhibition of tumor metastasis by different agents is at least partly associated with the ability to interfere with cellular functions such as adhesiveness, motility and invasiveness. Certainly effective treatment of metasta...