نتایج جستجو برای: cell penetrating peptide

تعداد نتایج: 1805636  

Journal: :Biochimica et biophysica acta 2012
Ana M S Cardoso Sara Trabulo Ana L Cardoso Annely Lorents Catarina M Morais Paula Gomes Cláudia Nunes Marlene Lúcio Salette Reis Kärt Padari Margus Pooga Maria C Pedroso de Lima Amália S Jurado

The present work aims to gain insights into the role of peptide-lipid interactions in the mechanisms of cellular internalization and endosomal escape of the S4(13)-PV cell-penetrating peptide, which has been successfully used in our laboratory as a nucleic acid delivery system. A S4(13)-PV analogue, S4(13)-PVscr, displaying a scrambled amino acid sequence, deficient cell internalization and dru...

Journal: :Biochemical and Biophysical Research Communications 2009

Journal: :Biochimica et Biophysica Acta (BBA) - Biomembranes 2014

Journal: :Cellular and Molecular Life Sciences 2008

Journal: :The Journal of Biological Chemistry 2009
Gohar Ter-Avetisyan Gisela Tünnemann Danny Nowak Matthias Nitschke Andreas Herrmann Marek Drab M. Cristina Cardoso

Arginine-rich peptides are a subclass of cell-penetrating peptides that are taken up by living cells and can be detected freely diffusing inside the cytoplasm and nucleoplasm. This phenomenon has been attributed to either an endocytic mode of uptake and a subsequent release from vesicles or to direct membrane penetration (transduction). To distinguish between both possibilities, we have blocked...

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