the present study was designed to investigate the anti-melanogenic and cytotoxic activities of methanol extract of phlomis kurdica. the antioxidant and anti-tyrosinase activity of meoh extract from p. kurdica (mpk) were examined by dpph radical scavenging and mushroom tyrosinase activity assays (in vitro), respectively. furthermore, the effect of mpk on the melanin content, cellular tyrosinase ...

Phagocytosis and cellular cytotoxicity by mononuclear phagocytes of blood and intestinal mucosa were studied in patients with Crohn's disease and large bowel neoplasms. Antibody coated sheep erythrocytes were used for phagocytic assays and cellular cytotoxicity in vitro was measured by 24 hour isotope release from 75Selenium methionine-labelled RPMI 4788 human cancer cell cultures in the presen...

Graphene oxide (GO) is currently developed for biomedical applications as a promising nanoplatform drug delivery, phototherapy, and biosensing. As consequence, its safety cytotoxicity issues have attracted extensive attention. It has been demonstrated that GO causes an increase of intracellular oxidative stress, likely leading to inhibition cell proliferation. Being one the main reductive subst...

Enhancement of multiple effector functions of an antibody may be a promising approach for antibody therapy. We have previously reported that fucose removal from Fc-linked oligosaccharides greatly enhances antibody-dependent cellular cytotoxicity (ADCC) of therapeutic antibodies. Here, we report a unique approach to enhance complement-dependent cytotoxicity (CDC), another important effector func...

Article history: Received 25 September 2015 Received in revised form 28 September 2015 Accepted 28 September 2015 Available online 30 September 2015 ies from an HIV-1 subtype A-infected donor. Two antibodies recognized epitopes revealed within the CD4-bound conformation of Env, while one recognized anepitopewithin theV3 loop of Env. Despite identifying an anti-V3 antibody capable of mediating A...

Simple antibodies or vector-induced T cell immunity are unable to provide broad immunity to HIV. Although broadly reactive neutralising antibodies are a goal of vaccination, this remains elusive. There is growing evidence that HIV-specific antibodies that mediate their activity via the Fc-receptor, such as antibody dependent cellular cytotoxicity (ADCC), have an important role in controlling HI...

Highly sensitive reporter-gene assays have been developed that allow the precise quantification of both direct vascular endothelial growth factor-A neutralizing activity bevacizumab and ability to activate antibody dependent cellular cytotoxicity. The use these analyzes samples from patients with ovarian cancer following four cycle treatment revealed a close correlation between cytotoxicity act...

Edaravone, an antioxidant and radical scavenger, showed protective effects against oxidative stress-like condition. Paraquat (PQ) is a toxic herbicide considerable evidence suggests that oxidative stress and mitochondrial dysfunction contribute to PQ toxicity. In this study, protective effect of edaravone against PQ induced toxicity and reactive oxygen species (ROS) generation in A549 cells and...