The recruitment dynamics of lipids in the biomembrane is believed to play an important role in a variety of cellular processes. In this work, we investigate the nanoparticle-induced recruitment dynamics of lipids in the heterogeneous phospholipid bilayers of distearoyl-phosphatidylcholine (DSPC) and dioleoyl-phosphatidylglycerol (DOPG) via coarse-grained molecular dynamics simulations. Three dy...

Although cell membranes are packed with proteins mingling with lipids, remarkably little is known about how proteins interact with lipids to carry out their function. Novel analytical tools are revealing the astounding diversity of lipids in membranes. The issue is now to understand the cellular functions of this complexity. In this Perspective, we focus on the interface of integral transmembra...

Lipids comprise a significant, highly plastic proportion of the biomass in haptophytes, ubiquitous, globally and genetically diverse clade photosynthetic microalgae. Recent studies have investigated cellular lipidomes disparate, individual species haptophytes under nutrient-replete nutrient-limited conditions, but not how vary across larger evolutionary or its ecological functional groups. We c...

Lipids in Platelets Lipids are low molecular weight, typically hydrophobic and amphipathic molecules found in all cell types. They are either generated endogenously or incorporated into cells from dietary sources. Their formation, trafficking, and metabolism are tightly controlled by cellular proteins, which include members of large families of phospholipases, lipid synthetases, ligases, oxidas...

In recent years, much interest has been generated by the idea that nitrosative stress plays a role in aetiology of human diseases, such as atherosclerosis, inflammation, cancer, and neurological diseases. The chemical changes mediated reactive nitrogen species (RNS) are detrimental to cell function, because they can cause nitration, which alter structures cellular proteins, DNA, lipids, hence, ...

Background: Despite the high safety profile of peptide-based vaccines over conventional counterparts, the inability of small peptides to produce a strong immune response represents the main obstacle for the development of these types of vaccines. Introducing a self-adjuvanting moiety such as fluorinated lipids can overcome this problem. We have recently demonstrated that fluorinated lipids can ...