Tooth root formation is initiated by the elongation of Hertwig’s epithelial root sheath (HERS). HERS cells are widely accepted to control root formation, but the mechanisms regulating HERS growth have not been elucidated. To solve this problem, we have established a new culture method for postnatal mouse mandibular molars and, using it, examined the role of insulin-like growth factor-I (IGF-I) ...

BACKGROUND Cyclosporin A (CsA) is a known immunosuppressive agent and can be considered as a lifesaving drug in the organ transplantation cases. However, it is associated with many side-effects on different tissues and body organs including the periodontal tissues. The present animal study was undertaken to evaluate the effects of CsA targeting the tissue triad of periodontal tissues, i.e., gin...

background and aim: the main goal of endodontic treatments is eliminating the etiologic factors of pulpal and periapical diseases as well as maintaining this condition via providing a hermetic seal between periodontium and root canal system. if these were not possible through orthograde approach, periradicular surgery and root-end filling are indicated. review of literature: different materials...

PURPOSE The purpose of this animal study was to perform a histological and histomorphometric analysis in order to elucidate the effect of fibroblast growth factor-2 (FGF-2) on injured periodontal ligament (PDL) and cementum after tooth replantation in dogs. METHODS The roots of 36 mandibular premolars from six mongrel dogs were used in this study. The roots were randomly divided into three gr...

BACKGROUND Inorganic pyrophosphate (PP(i)) is a physiologic inhibitor of hydroxyapatite mineral precipitation involved in regulating mineralized tissue development and pathologic calcification. Local levels of PP(i) are controlled by antagonistic functions of factors that decrease PP(i) and promote mineralization (tissue-nonspecific alkaline phosphatase, Alpl/TNAP), and those that increase loca...

The most common root malformations in humans arise from either developmental disorders of the root alone or disorders of radicular development as part of a general tooth dysplasia. The aim of this review is to relate the characteristics of these root malformations to potentially disrupted processes involved in radicular morphogenesis. Radicular morphogenesis proceeds under the control of Hertwi...

Although defect or defect morphology continue to prevail as the basis for treatment in current periodontology, diagnosis must be the basis for periodontal therapy (20). The periodontal therapist should aim at eliminating the causative and contributing factors of the disease. Based on diagnosis, the integration of reparativeproceduresmayleadtodefinitivetreatment,which canhelpmaintaintherapeuticr...

background: cyclosporin a (csa) is a known immunosuppressive agent and can be considered as a lifesaving drug in the organ transplantation cases. however, it is associated with many side-effects on different tissues and body organs including the periodontal tissues. the present animal study was undertaken to evaluate the effects of csa targeting the tissue triad of periodontal tissues, i.e., gi...

Among various types of gingival enlargements, Peripheral ossifying fibroma (POF) is a rare entity, which is nonneoplastic in nature and arises due to trauma, plaque, calculus, restorations and dental appliances. The term peripheral ossifying gingival growth was coined by Eversole and Rovin. Various synonyms are used for this gingival growth, like peripheral cementifying fibroma, ossifying fibro...

The life-span of the tooth is intimately-associated with healthiness of periodontal ligament (PDL) which is a connective tissue situated between bone and cementum that covers tooth root surface. However, once this tissue is severely damaged by deep caries, periodontitis, and trauma, this leads to severe difficulty in its regeneration, resulting in tooth loss and decreased quality of life. The d...