Unitary synaptic currents in hippocampus show small variability. Experimental evidence suggests that the neuron is endowed with mechanisms to reduce location-dependent differences in amplitude and time course of synaptic events, contributing to small variability. These mechanisms may allow the neuron to count individual quanta and thereby linearize integration of unitary events.

One of today’s most challenging problems in office automation is the integration of Workflow Management Systems (WFMS) into legacy systems and their combination with other cooperative applications. For the integration of legacy systems the WFMS provides the central "control flow component" which calls a program to be executed in order to process single atomic activities from the point of view o...

In this paper, we consider each neural network as a point in a multi-dimensional problem space and suggest a crossover that locates the central point of a number of neural networks. By this, genetic algorithms can spend more time around attractive areas. We also apply representational normalization to neural networks to maintain genotype consistency in crossover. For the normalization, we utili...

sodium and calcium ion channels (Figure 1B,C). This discovery has widespread implications for the ways neurons integrate the many thousands of synaptic inputs they receive. Theoretical studies pioneered by Rall [2] laid the foundations for the way neuroscientists think about synaptic integration. He suggested that dendrites behave like electrical filters, reducing the amplitude of synaptic pote...