Cervical cancer is the second most common gynecological cancer among Korean women. While nationwide screening program has developed, the pathogenesis of cervical cancer is unknown. The aim of this study was to compare the protein expression profiles between cervical squamous carcinomas and normal cervical tissues in order to identify proteins that are related to the cancer. Three cervical cance...

Background: Limited and fixed number of ovarian follicles undergo reducing changes from birth till menopause. In cancerous patients who exposed to sterilizing treatments such as chemotherapy, follicle decrease is faster and dominant. Main fertility preservation technique for these patients is ovarian cryopreservation and transplantation. Reanastomosis between recipient site and invader tissue i...

An extensive remodelling process, referred to as cervical ripening, takes place in the cervical tissue during pregnancy and labour. It is recognized as softening and dilation of the cervical canal, and starts as a slow process during pregnancy, becoming rapid close to partum. In this study we focus on cytokines as possible mediators of this final remodelling. mRNA levels for interleukin (IL)-8,...

Cervical dysfunction contributes to a significant number of preterm births and is a common cause of morbidity and mortality in newborn infants. Cervical dysfunction is related to weakened load bearing properties of the collagen-rich cervical stroma. However, the mechanisms responsible for cervical collagen changes during pregnancy are not well defined. It is known that blood flow and oxygen ten...

although rare, synovial sarcoma is the most common malignant non-rhabdomyosarcomatous soft tissue sarcoma in children and adolescents. synovial sarcoma typically involves the soft tissues of the extremities, especially near large joints, but it can occur anywhere in the body in locations far from joint spaces. although this tumor typically affects adults in their fourth decade of life, nearly h...

an invasive mole is a rare form of gestational trophoblastic disease in which the molar tissue invades into the deep myometrium, cervical stroma, blood vessels or extrauterine sites. this report is of an invasive mole of spleen that has originated from an ectopic pregnancy, which was primarily though to be a choriocarcinoma.

To establish Lactate dehydrogenase (LDH) isoenzyme is a biochemical tumor marker in cervical carcinoma patients for diagnosis and treatment monitoring of the disease. The Serum and cervical tissue LDH isoenzyme was analyzed qualitatively by Poly Acrylamide Disc Gel Electrophoresis method. The total LDH activity was estimated quantitatively by the method of UV spectrophotometry. 50 untreated cer...

In patients with primary progressive (PP) multiple sclerosis, brain MRI lesion activity and burden are low, despite the presence of severe neurological impairment. On the contrary, the degree of cord atrophy and diffuse tissue damage in the brain and cervical cord have been found to be associated with clinical disability. Against this background, this study aimed at providing an in vivo indirec...

The human cervix is a tissue target of sex steroid hormones as estradiol (E2) which exerts its action through of the estrogen receptors alpha and beta (ER-α and ER-β). In this study we investigated the expression of ER-α and ER-β in human invasive cervical carcinomas using immunohistochemistry and RT-PCR analyses and compared with that observed in the corresponding normal tissue. The results sh...

OBJECTIVE Previous studies have demonstrated that levels of hypermethylation of paired boxed gene 1 in cervical tissues are associated with the grades of severities of cervical neoplasia in women, which suggests that testing for DNA methylation has a potential role in neoplasma screening. In this study, by testing methylation levels of PAX1 genes in cervical scrapings and cervical tissues of di...