isolated skeletal metastasis to the bony calvarium is extremely rare in patients with squamous cell carcinoma of the uterine cervix. we describe the clinical and imaging findings in a case of squamous cell carcinoma of the uterine cervix with metastases to the bony calvarium as the sole site of metastasis. the patient was a 65-year-old woman with squamous cell carcinoma of the uterine cervix, f...

INTRODUCTION Uterine cervix cancer is an important public health problem in Tunisia. In this study, we report trends in the incidence of adenocarcinoma and squamous cell carcinoma of the cervix uteri in the central region of Tunisia during 1993-2006. DESIGN Data were obtained from the Cancer Registry of the Center of Tunisia which registers invasive cancer cases by active methods. Five-year a...

For many decades, the epidemiological finding of females who have cervical cancer was identified as being suggestive of a sexually transmitted process and many biological agents were proposed as being responsible. In order to understand the contributions of epidemiological and laboratory methods to identifying cervical cancer etiology, this paper aimed to provide an historical review of the acc...

Background & Objectives: Tumor diathesis (TD) is defined as granular proteinaceous precipitates on slide surface of cytologic smears. It is found in the background of smears of invasive carcinoma but not in all cases. The aim of present study was to determine the prevalence of TD in cervicovaginal smears from patients with uterine cervix carcinoma. Methods: Cytological smears and histological ...

Graphical abstract Abstract The phenomenal extracellular matrix (ECM) remodelling of the cervix that precedes myometrial contraction labour at term or preterm appears to share some common mechanisms with occurrence, growth, invasion and metastasis cervical carcinoma. Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases pivotal complex tissue modulation includes degradation, exchan...

Gynecologic malignancies may have similar histological characteristics. This may lead to difficulties in determining the origin of the cancer and to distinguish a synchronous neoplasm from a metastatic cancer in advanced cases. Recently, we treated a 59-year-old patient with adenocarcinoma of the uterine cervix, endometrium, fallopian tubes, and ovaries. It was difficult to determine whether th...

Cancer of the uterine cervix is the 5th most deadly type of female cancer [1]. It is clearly demonstrated that HPV infection is the necessary, but not the sufficient cause of most cervical cancers [2]. The association between cancer of the uterine cervix and HPV is unique because no other human cancer is dependent on a single infectious factor for its development [3]. Worldwide, HPV types 16 an...

UNLABELLED THE BACKGROUND: Ribonuclease L (RNASEL), encoding the 2'-5'-oligoadenylate (2-5A)-dependent RNase L, is a key enzyme in the interferon induced antiviral and anti-proliferate pathway. Mutations in RNASEL segregate with the disease in prostate cancer families and specific genotypes are associated with an increased risk of prostate cancer. Infection by human papillomavirus (HPV) is the ...

Small cell carcinoma of the uterine cervix is rare. It is estimated that 10% of patients with small-cell lung cancer have syndrome of inappropriate secretion of antidiuretic hormone (SIADH) and hyponatremia has been reported to be significantly associated with a poor prognosis. A proportion of small cell carcinoma of the uterine cervix exhibit neuroendocrine characteristics as revealed by immun...