The paper presents a differential equation model for the feedback mechanisms between gonadotropin-releasing hormone (GnRH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), development of follicles and corpus luteum, and the production of estradiol (E2), progesterone (P4), inhibin A (IhA), and inhibin B (IhB) during the female menstrual cycle. Compared to earlier human cycle models...

background: the differential efficacy between long gnrh agonist with antagonist can partly be due to the preexisting differences in the early antral follicles before ovarian stimulation. objective: to compare the effect of pretreatment by estradiol with gnrh antagonist on antral follicular size coordination and basal hormone levels in gnrh antagonist protocol. materials and methods: on cycle da...

OBJECTIVE To evaluate the effects of the GnRH antagonist cetrorelix on the gonadal axis in patients with polycystic ovary syndrome (PCOS). DESIGN Observational clinical study. SETTING Academic research center. PATIENT(S) Ten patients with PCOS and 10 controls with normal ovulation. INTERVENTION(S) Patients received a daily cetrorelix injection (0.25 mg SC at 9:00 am) for 6 days, startin...

The expression of GnRH (GnRH-I, LHRH) and its receptor as a part of an autocrine regulatory system of cell proliferation has been demonstrated in a number of human malignant tumors, including cancers of the ovary. The proliferation of human ovarian cancer cell lines is time- and dose-dependently reduced by GnRH and its superagonistic analogs. The classical GnRH receptor signal-transduction mech...

PURPOSE Anti cancer drugs is one of the most important chemotherapeutic factors which can influence spermatogenesis process and germinal epithelium. Since dividing cells are mainly affected by anticancer drugs, the aim of the present study is to investigate the preventive effect of GnRH antagonist on spermatogenic defect produced by anticancer drugs. METHODS In the present study thirty adult ...

Clinical outcomes of dual trigger containing gonadotropin-releasing hormone agonist (GnRHa) and low dose human chorionic gonadotropin (hCG) compared with the standard for final oocyte maturation in normal responder patients GnRH Antagonist IVF-ICSI Cycles. A single centre prospective randomized comparative study conducted at a tertiary care infertility , Akanksha IVF centre, Janakpuri, New Delh...

effects of 28 days lead acetate (ioc, 500, 1000 ppm) treatment on hypertension ami relationship between blood lead levels and hypertension in male. spraguc-dawley rats were studied. results of this study showed tlxat lead acetate treatment did run decrease, body wcight or water consumption, except for lead acetate (1000 ppm) and sodium acetate (500 ppm) which increased fluid consumption when co...