Coronary collaterals preserve left ventricular (LV) function during coronary occlusion by reducing myocardial ischemia and may directly influence LV compliance. We aimed to re-evaluate the relationship between coronary collaterals, measured quantitatively with a pressure wire, and simultaneously recorded LV contractility from conductance catheter data during percutaneous coronary intervention (...

BACKGROUND Little is known about the vasomotor function of human coronary collateral vessels. The purpose of this study was to examine collateral flow under a strong sympathetic stimulus (cold pressor test, CPT). METHODS In 30 patients (62 +/- 12 years) with coronary artery disease, two subsequent coronary artery occlusions were performed with random CPT during one of them. Two minutes before...

BACKGROUND Rapid loss of collateral support has been reported after percutaneous coronary intervention (PCI), leaving the myocardium susceptible to subsequent infarction. However, well-developed collaterals have been found in normal hearts, suggesting that collaterals exist even in the absence of an ischemic stimulus. We assessed the plasticity and determinants of collateral supply after PCI. ...

CONTEXT Development of the cultural formulation interview (CFI) in DSM-5 required validation for cross-cultural and global use. AIMS To assess the overall value (OV) of CFI in the domains of feasibility, acceptability, and utility from the vantage points of clinician-interviewers, patients and accompanying relatives. SETTINGS AND DESIGN We conducted cross-sectional semi-structured debriefin...

Large-scale surveys frequently assess smoking-related attitudes, self-efficacy and intention to understand differences in smoking behavior. However, a critical assumption is that measures of these determinants should be equivalent across different subgroups of a target population. The current study examined the factorial invariance of measures of smoking-related attitudes, self-efficacy, and in...

BACKGROUND Complement Factor I (CFI) is a serine protease with an important role in complement alternative pathway regulation. Complete factor I deficiency is strongly associated with severe infections. Approximately 30 families with this deficiency have been described worldwide. PATIENTS AND METHODS We have studied five new Spanish families suffering from CFI deficiency. From 19 screened peo...

INTRODUCTION Takotsubo cardiomyopathy (TCM) is a life-threatening systemic consequence early after subarachnoid hemorrhage (SAH), but precise hemodynamics and related outcome have not been studied. The purpose of this study was to investigate the TCM-induced cardiac function by transpulmonary thermodilution and its impact on clinical outcome of SAH. METHODS We retrospectively analyzed 46 cons...

Applications written in low-level languages without type or memory safety are especially prone to memory corruption. Attackers gain code execution capabilities through such applications despite all currently deployed defenses by exploiting memory corruption vulnerabilities. Control-Flow Integrity (CFI) is a promising defense mechanism that restricts open control-flow transfers to a static set o...

A 71-year-old woman with myelodysplastic syndrome was admitted because of fever and treated with antibacterial agents. On the second hospital day, she presented with dysarthria and right arm paresis and was diagnosed as cerebral infarction. On the fourth hospital day, she suddenly died. An autopsy revealed a left atrial mass caused by mucormycosis (Pictures 1, 2). Systemic fungal embolism, incl...