BACKGROUND The use of repeated intravenous infusions of EDTA, which has become known as "chelation therapy," has been promoted for treating intermittent claudication as well as a wide range of other disorders. Multiple reports of excellent results in large numbers of patients have encouraged the use of this regimen. The lack of well-controlled studies substantiating the benefits of this treatme...

Background. Hematologic improvement (HI) occurs in some patients with acquired anemias and transfusional iron overload receiving iron chelation therapy (ICT) but there is little information on transfusion status after stopping chelation. Case Report. A patient with low IPSS risk RARS-T evolved to myelofibrosis developed a regular red blood cell (RBC) transfusion requirement. There was no respon...

PURPOSE OF REVIEW EDTA chelation therapy has been in off-label use for the treatment of atherosclerosis. We review the results of the first large-scale randomized trial of this treatment. RECENT FINDINGS The trial to assess chelation therapy was a $30 million National Institutes of Health-funded study of the safety and efficacy of EDTA-based chelation infusions in 1708 post-myocardial infarct...

Although it is known that Candida albicans causes endothelial cell injury, in vitro and in vivo, the mechanism by which this process occurs remains unknown. Iron is critical for the induction of injury in many types of host cells. Therefore, we investigated the role of iron in Candida-induced endothelial cell injury. We found that pretreatment of endothelial cells with the iron chelators phenan...

Chelation challenge testing has been used to assess the body burden of various metals. The best-known example is EDTA challenge in lead-exposed individuals. This study assessed diagnostic chelation challenge with dimercaptosuccinic acid (DMSA) as a measure of mercury body burden among mercury-exposed workers. Former employees at a chloralkali plant, for whom detailed exposure histories were ava...

electroplating industry wastewater (eiw) characterized by high chemical oxygen demand (cod) is a big source of water and air contamination with heavy metals. the formation of cyanide complex with heavy metals is responsible for its elevated cod. the concentration of heavy metals in eiw can be removed by the use of different precipitating agents (sulfide and hydroxide). but the major bottleneck ...

abstractthe ability of hesperidin (hp) to form complexes with five metals; cobalt, nickel, zinc, calcium and magnesium was investigated. the complexation was studied using u.v spectroscopic titration, in methanol as well as aqueous buffer solutions (physiological conditions). potential complexes were studied by ir and nmr spectroscopy, melting point and their solubility were also evaluated. the...